Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Polymerase chain reaction for detection of carcinoembryonic antigen-expressing tumor cells on milky spots of the greater omentum in gastric cancer patients: A pilot study
Autore:
Sakakura, C; Hagiwara, A; Shirasu, M; Yasuoka, R; Fujita, Y; Nakanishi, M; Aragane, H; Masuda, K; Shimomura, K; Abe, T; Yamagishi, H;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Digest Surg, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med, Dept Hyg, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 5, volume: 95, anno: 2001,
pagine: 286 - 289
SICI:
0020-7136(20010920)95:5<286:PCRFDO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBON-ADSORBED MITOMYCIN; PERITONEAL DISSEMINATION; MOLECULAR-DETECTION; PERIPHERAL-BLOOD; MALIGNANT-CELLS; BONE-MARROW; LYMPH-NODES; CARCINOMA; GASTRECTOMY; IMPLANTATION;
Keywords:
RT-PCR; milky spot; gastric cancer; peritoneal dissemination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sakakura, C Kyoto Prefectural Univ Med, Dept Digest Surg, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 028566, Japan
Citazione:
C. Sakakura et al., "Polymerase chain reaction for detection of carcinoembryonic antigen-expressing tumor cells on milky spots of the greater omentum in gastric cancer patients: A pilot study", INT J CANC, 95(5), 2001, pp. 286-289

Abstract

Our recent studies indicate that omental milky spots are frequently involved in the early stage of peritoneal cancer dissemination. We have used carcinoembryonic antigen (CEA)-specific RT-PCR for omental milky spots to predict peritoneal recurrence in gastric cancer patients. CEA mRNA was found to be positive in both 10 peritoneal washes and 16 greater omenta of 30 gastric cancer patients, including all 6 patients who showed positive results forboth cytology and RT-PCR of peritoneal wash and omentum. Three of the 6 cases with positive RT-PCR in the greater omentum but not in the peritoneal wash showed recurrence of peritoneal carcinomatosa within 2 years after operation. Micrometastasis on omental milky spots was histologically confirmed in 6 of 30 gastric cancer cases. Non-specific band was detected only in theomentum of 1 case of 15 benign disease (7%), but not in peritoneal washes (0%), probably due to weak expression of CEA in mesothelial cells. Our results show that CEA- specific RT-PCR targeting micro-metastases on omental milky spots is more sensitive than targeting the peritoneal wash or conventional cytology, and suggest that this method is useful for the prediction of peritoneal recurrence in gastric cancer patients. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:50:15