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Titolo:
Macromolecular crowding and its role as intracellular signalling of cell volume regulation
Autore:
Al-Habori, M;
Indirizzi:
Sanaa Univ, Fac Med & Hlth Sci, Dept Clin Biochem, Sanaa, Yemen Sanaa Univ Sanaa Yemen Med & Hlth Sci, Dept Clin Biochem, Sanaa, Yemen
Titolo Testata:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
fascicolo: 9, volume: 33, anno: 2001,
pagine: 844 - 864
SICI:
1357-2725(200109)33:9<844:MCAIRA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
K-CL COTRANSPORT; PROTEIN DISULFIDE-ISOMERASE; DOG RED-CELLS; PERFUSED-RAT-LIVER; AMINO-ACID-TRANSPORT; SKELETAL-MUSCLE; NA+/H+ ANTIPORTER; ION-TRANSPORT; OKADAIC ACID; GLYCOGEN-SYNTHESIS;
Keywords:
macromolecular crowding; cell volume; swelling-dependent dephosphorylation; shrinkage-dependent phosphorylation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
191
Recensione:
Indirizzi per estratti:
Indirizzo: Al-Habori, M Sanaa Univ, Fac Med & Hlth Sci, Dept Clin Biochem, POB 19065,Sanaa, Yemen Sanaa Univ POB 19065 Sanaa Yemen m, POB 19065, Sanaa, Yemen
Citazione:
M. Al-Habori, "Macromolecular crowding and its role as intracellular signalling of cell volume regulation", INT J BIO C, 33(9), 2001, pp. 844-864

Abstract

Macromolecular crowding has been proposed as a mechanism by means of whicha cell can sense relatively small changes in volume or, more accurately, the concentration of intracellular solutes. According to the macromolecular theory, the kinetics and equilibria of enzymes can be greatly influenced bysmall changes in the concentration of ambient, inert macromolecules. A 10%change in the concentration of intracellular proteins can lead to changes of up to a factor of ten in the thermodynamic activity of putative molecular regulatory species, and consequently, the extent to which such regulator(s) may bind to and activate membrane-associated ion transporters. The aim of this review is to examine the concept of macromolecular crowding and how it profoundly affects macromolecular association in an intact cell with particular emphasis on its implication as a sensor and a mechanism through which cell volume is regulated. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:18:09