Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Kinin system in lupus nephritis
Autore:
Dellalibera-Joviliano, R; Reis, ML; Donadi, EA;
Indirizzi:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Med, Div Clin Immunol, BR-14049900 Ribeirao Preto, SP, Brazil Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCo Preto, SP, Brazil Univ Sao Paulo, Fac Pharmaceut Sci, Pharmacol Lab, BR-14049900 Ribeirao Preto, SP, Brazil Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCo Preto, SP, Brazil
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 9-10, volume: 1, anno: 2001,
pagine: 1889 - 1896
SICI:
1567-5769(200109)1:9-10<1889:KSILN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; HUMAN NEUTROPHILS; TISSUE PROKALLIKREIN; SYNOVIAL-FLUID; IN-VIVO; PLASMA; KALLIKREIN; IDENTIFICATION; ERYTHEMATOSUS; DISEASES;
Keywords:
systemic lupus erythematosus (SLE); kininogens; kallikreins; kininase II; kinins; lupus nephritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Donadi, EA Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Med, Div Clin Immunol, Avenida Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP, Brazil UnivSao Paulo Avenida Bandeirantes 3900 Ribeirao Preto SP Brazil BR-14049900 BC
Citazione:
R. Dellalibera-Joviliano et al., "Kinin system in lupus nephritis", INT IMMUNO, 1(9-10), 2001, pp. 1889-1896

Abstract

There are few studies regarding the evaluation of the kinin system in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the plasma levels of high-molecular weight kininogen (HKg), low-molecular weight kininogen (LKg) and plasma kallikrein, the plasma activity of tissue kallikrein and kininase II, and urinary kallikrein and kininase II activities in patients presenting with active lupus nephritis. A total of 30 patients (29 women) aged 21-62 years (median = 39) and 30 controls matched to the patients for sex and age were studied. Patients presenting with other underlying diseases or using drugs, which could interfere with the kinin system,were excluded. HKg and LKg levels were indirectly evaluated by ELISA. Plasma kallikrein, tissue kallikrein, and kininase II were evaluated by their enzymatic activity on selective substrates. The Mann-Whitney test was used for statistical analysis. HKg, LKg and plasma kallikrein levels were significantly increased in patients ( p < 0.001, for each comparison), Similarly. tissue kallikrein and kininase II activities were significantly increased in plasma and urine of patients ( p < 0.001, for each comparison). In urine,the activities of tissue kallikrein and kininase II were at least seven times higher than those seen in the plasma of patients. These results indicate that the kinin system is involved in the acute manifestations of lupus nephritis. Kinins may facilitate immunecomplex deposition and may induce the release of other pro-inflammatory mediators, including cytokines actively involved in the pathogenesis of lupus nephritis. (C) 2001 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 20:53:18