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Titolo:
Histamine inhibits chemotaxis, phagocytosis, superoxide anion production, and the production of TNF alpha and IL-12 by macrophages via H-2-receptors
Autore:
Azuma, Y; Shinohara, M; Wang, PL; Hidaka, A; Ohura, K;
Indirizzi:
Osaka Dent Univ, Dept Pharmacol, Hirakata, Osaka 5731121, Japan Osaka DentUniv Hirakata Osaka Japan 5731121 rakata, Osaka 5731121, Japan
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 9-10, volume: 1, anno: 2001,
pagine: 1867 - 1875
SICI:
1567-5769(200109)1:9-10<1867:HICPSA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; RESPIRATORY BURST OXIDASE; NEUTROPHIL NADPH-OXIDASE; OXIDATIVE-METABOLISM; IMMUNE FUNCTIONS; ACTIVATION; LYMPHOCYTES; PROLIFERATION; QUINOLONES; MODULATION;
Keywords:
histamine; macrophage; phagocytosis; TNF alpha; IL-12; H-2-histamine receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Azuma, Y Osaka Dent Univ, Dept Pharmacol, 8-1 Kuzuhahanazono Cho, Hirakata, Osaka 5731121, Japan Osaka Dent Univ 8-1 Kuzuhahanazono Cho Hirakata Osaka Japan 5731121
Citazione:
Y. Azuma et al., "Histamine inhibits chemotaxis, phagocytosis, superoxide anion production, and the production of TNF alpha and IL-12 by macrophages via H-2-receptors", INT IMMUNO, 1(9-10), 2001, pp. 1867-1875

Abstract

Histamine is released from stimulated basophils and mast cells. and plays an important role in the pathogenesis of allergic inflammatory processes. In vitro treatment of macrophages with histamine resulted in inhibition of chemotaxis. Moreover, histamine at 10(-5) M markedly inhibited the production of superoxide anions by both opsonized zymosan-A and phorbol 12-myristate13-acetate (PMA) stimulated macrophages and histamine at a concentration range of 10(-7) to 10(-5) M significantly inhibited phagocytosis of Escherichia coli by macrophages. In addition, H-2-selective receptor agonist dimaprit resulted in inhibition of macrophage chemotaxis and markedly inhibited the production of superoxide anion by PMA-stimulated macrophages and phagocytosis of E. coli by macrophages. On the other hand, histamine and dimaprit both resulted in a concentration-dependent inhibition of lipopolysaccharide- induced production of TNF alpha and IL-12 by macrophages. These results suggest that histamine and dimaprit may inhibit chemotaxis, phagocytosis, superoxide anion production, and the production of TNF alpha and IL-12 by macrophages via H-2-histamine receptors. (C) 2001 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:28:25