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Titolo:
Prevention of experimental septic shock by pretreatment of mice with muramyl peptides
Autore:
Meshcheryakova, E; Guryanova, S; Makarov, E; Alekseeva, L; Andronova, T; Ivanov, V;
Indirizzi:
Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997,Russia Russian Acad Sci Moscow Russia 117997 ioorgan Chem, Moscow 117997,Russia
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 9-10, volume: 1, anno: 2001,
pagine: 1857 - 1865
SICI:
1567-5769(200109)1:9-10<1857:POESSB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR NECROSIS FACTOR; BACTERIAL-CELL WALL; CACHECTIN; TOXICITY; LIPOPOLYSACCHARIDE; ENDOTOXIN; MDP;
Keywords:
septic shock; muramyl peptides; protection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Meshcheryakova, E Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Miklukho Maklaya 16-10,V-437, Moscow 117997, Russia Russian Acad Sci Miklukho Maklaya 16-10,V-437 Moscow Russia 117997
Citazione:
E. Meshcheryakova et al., "Prevention of experimental septic shock by pretreatment of mice with muramyl peptides", INT IMMUNO, 1(9-10), 2001, pp. 1857-1865

Abstract

Muramyl peptides, immunostimulators with macrophage as a main target cell,are used for protecting mice from LPS-lethality (the experimental model ofseptic shock). Different protocols of pretreatment mice by muramyl peptides lead to opposite results. LPS and glycopeptides act synergistically in the induction of lethal shock. when mice receive peptides I day prior to lethal dose of LPS. However, extension of the period between the peptide and LPS injections to 6 days cancels the effect of synergism. Moreover, a 14-day interval between the same injections leads to protection of 70-90% animals from the toxic effect of LPS. Lipophilic analogs require 10-100 lower concentrations to protect the animals than the parent highly hydrophilic glycopeptides. Production of TNF, IL-1 and phagocytosis by macrophages was studiedwithin the periods corresponding to "synergism" and LPS-resistance. High level of macrophage activity was observed during the "synergism" period. LowTNF production and reduced macrophage phagocyte activity corresponded to LPS-resistant state. These results partly explain the LPS-unresponsiveness in mice after their pretreatment by muramyl peptides. (C) 2001 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:44:10