Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappa B in RAW 264.7 macrophages
Autore:
Pae, HO; Cho, H; Oh, GS; Kim, NY; Song, EK; Kim, YC; Yun, YG; Kang, CL; Kim, JD; Kim, JM; Chung, HT;
Indirizzi:
Wonkwang Univ, Dept Neurosurg, Iksan, Chonbug, South Korea Wonkwang Univ Iksan Chonbug South Korea urg, Iksan, Chonbug, South Korea Wonkwang Univ, Dept Pediat, Iksan, Chonbug, South Korea Wonkwang Univ Iksan Chonbug South Korea iat, Iksan, Chonbug, South Korea Wonkwang Univ, Coll Pharm, Iksan, Chonbug, South Korea Wonkwang Univ Iksan Chonbug South Korea arm, Iksan, Chonbug, South Korea Wonkwang Univ, Med Resources Res Ctr, Iksan, Chonbug, South Korea WonkwangUniv Iksan Chonbug South Korea Ctr, Iksan, Chonbug, South Korea
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 9-10, volume: 1, anno: 2001,
pagine: 1849 - 1855
SICI:
1567-5769(200109)1:9-10<1849:BFPCIT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LPS-ACTIVATED MACROPHAGES; CELL-LINE RAW-264.7; SMOOTH-MUSCLE CELLS; INTESTINAL INFLAMMATION; LIPOPOLYSACCHARIDE; SESQUITERPENE; INDUCTION; YOMOGIN; BRAIN; MICE;
Keywords:
Bakulchiol; Psoralea corylifolia; nitric oxide; inducible nitric oxide synthase mRNA; nuclear transcription factor-kappa B; anti-inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, HT Wonkwang Univ, Sch Med, Dept Microbiol & Immunol, Chonju, South Korea Wonkwang Univ Chonju South Korea Immunol, Chonju, South Korea
Citazione:
H.O. Pae et al., "Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappa B in RAW 264.7 macrophages", INT IMMUNO, 1(9-10), 2001, pp. 1849-1855

Abstract

A large amount of nitric oxide (NO) production following the induction of inducible NO synthase (iNOS) gene has been implicated in the pathogenesis of inflammatory diseases. A phenolic compound, bakuchiol, isolated from Psoralea corylifolia L. (Leguminosae) inhibited NO production in RAW 264.7 macrophages activated with interferon-gamma and lipopolysaccharide. The mechanistic studies showed that bakuchiol inhibited the expression of iNOS mRNA through the inactivation of nuclear transcription factor-kappaB. Thus, bakuchiol may be a useful candidate for the development of a drug to treat inflammatory diseases related to iNOS gene over-expression. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:03:50