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Titolo:
Enhanced resistance to Sendai virus infection in DBA/2J mice with a botanical drug combination (Sinupret((R)))
Autore:
Schmolz, M; Ottendorfer, D; Marz, RW; Sieder, C;
Indirizzi:
Bionorica Arzeimittel GmbH, Neumarkt Opf, Germany Bionorica Arzeimittel GmbH Neumarkt Opf Germany , Neumarkt Opf, Germany Battelle Inst, Frankfurt, Germany Battelle Inst Frankfurt GermanyBattelle Inst, Frankfurt, Germany EDI GmbH, Reutlingen, Germany EDI GmbH Reutlingen GermanyEDI GmbH, Reutlingen, Germany
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 9-10, volume: 1, anno: 2001,
pagine: 1841 - 1848
SICI:
1567-5769(200109)1:9-10<1841:ERTSVI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; IMMUNITY;
Keywords:
Sendai virus; plant medicine; respiratory tract infection; T-lymphocytes; Muramyldipeptide; Ambroxol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Ottendorfer, D Battelle Inst, Regerstr 6, D-55127 Mainz, Germany Battelle Inst Regerstr 6 Mainz Germany D-55127 nz, Germany
Citazione:
M. Schmolz et al., "Enhanced resistance to Sendai virus infection in DBA/2J mice with a botanical drug combination (Sinupret((R)))", INT IMMUNO, 1(9-10), 2001, pp. 1841-1848

Abstract

It was investigated whether the botanical drug combination Sinupret is able to modulate the resistance of mice to a respiratory tract infection with Sendai virus ( Parainfluenza viridae) if given prophylactically to the animals. Three doses of Sinupret drops (SD) and Sinupret tablets (ST, p.o.), and two active controls, the chemical secretolytic ambroxol (p.o.) and the immunomodulator Muramyldipeptide (MDP, i.v.) were used. Test and reference substances were applied at days - 3 and - I before infection, except MDP, which was given once on day - I before infection. CD4 + and CD8 + lymphocyte subpopulations were measured after infection as indicators of immunological treatment response. Groups of 20 mice each were infected by intranasal application of Sendai virus under anaesthesia. We found that the I x and 5 x human doses of Sinupret drops significantly prolonged the survival times ( p < 0.05) compared to placebo. Additionally, ambroxol and MDP were comparablyless effective. In all groups, changes in CD4 + and CD8 + T-lymphocyte subpopulations of the peripheral blood were observed, but no clear relationship to the treatment results was seen. It was concluded that Sinupret increases the resistance to an experimentally induced respiratory tract infection in mice. Moreover, the effect of Sinupret was superior to that of an immunostimulant (MDP) and of a synthetic secretagogue (ambroxolhydrochloride). (C) 2001 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:28:05