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Titolo:
Neuropeptide degradation in naive and steroid-treated allergic saliva
Autore:
Albo, F; Antonangeli, R; Cavazza, A; Marini, M; Roda, LG; Rossi, P;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Neurosci, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 o Neurosci, I-00133 Rome, Italy Azienda Aspedaliera San Filippo Neri, Div Broncopneumol, Rome, Italy Azienda Aspedaliera San Filippo Neri Rome Italy ncopneumol, Rome, Italy Univ Roma Tor Vergata, Dipartimento Med Interna, Malattie Apparato Resp, Rome, Italy Univ Roma Tor Vergata Rome Italy a, Malattie Apparato Resp, Rome, Italy
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 9-10, volume: 1, anno: 2001,
pagine: 1777 - 1788
SICI:
1567-5769(200109)1:9-10<1777:NDINAS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; SUB-MANDIBULAR GLAND; SUBMANDIBULAR-GLAND; ENKEPHALIN HYDROLYSIS; BLOOD-STREAM; HUMAN-PLASMA; SUBSTANCE-P; RAT; PEPTIDE; SECRETION;
Keywords:
saliva; neuropeptides; proteolytic enzymes; allergy; therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Roda, LG Univ Roma Tor Vergata, Dipartimento Neurosci, Via Tor Vergata 135, I-00133Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133 aly
Citazione:
F. Albo et al., "Neuropeptide degradation in naive and steroid-treated allergic saliva", INT IMMUNO, 1(9-10), 2001, pp. 1777-1788

Abstract

The hydrolysis of neuropeptides and possible variations in hydrolysis following steroidal treatment, were examined in the presence of saliva collected from allergic volunteers; data obtained were compared to those obtained with a age and sex-matching group of healthy controls. The results reported indicate the presence of a statistically significant increase in the hydrolysis of the model substrate in allergic as compared to control saliva, and a reduction of substrate hydrolysis in treated as compared to naive allergic saliva. Total enzyme activity, the relative activity of the three classesof substrate-active enzymes (aminopeptidases, dipeptidylaminopeptidases, and dipeptidylcarboxypeptidases). the allergy-associated variations of theseactivities, and the variations associated to therapy were found to be different in male and female saliva, Specifically, in the controls, the lower level of hydrolysis evident in female as compared to male saliva appeared tobe principally induced by lower activity of aminopeptidases, Under allergic conditions, a sex-different increase in the activity of all three classesof substrate-active enzymes modified the hydrolysis pattern differently insamples obtained from male and female donors. Finally, pharmacological treatment induced opposite effects on the enzymes present in each sex: in malesaliva, the activity of all three classes of substrate-active enzymes-and,thus, of substrate hydrolysis-was reduced near to the levels measured in the controls. In female saliva, the reduction in the activity of aminopeptidases was coupled with an increase in the activity of dipeptidylaminopeptidases, causing substrate hydrolysis to remain near the levels measured in naive allergic, rather than control, saliva. (C) 2001 Elsevier Science BN. Allrights reserved.

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Documento generato il 20/01/20 alle ore 21:59:52