Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mycobacterial antigens attenuate late phase response, airway hyperresponsiveness, and bronchoalveolar lavage eosinophilia in a mouse model of bronchial asthma
Autore:
Hopfenspirger, MT; Parr, SK; Hopp, RJ; Townley, RG; Agrawal, DK;
Indirizzi:
Creighton Univ, Sch Med, Ctr Allergy Asthma & Immunol, Omaha, NE 68178 USACreighton Univ Omaha NE USA 68178 y Asthma & Immunol, Omaha, NE 68178 USA
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 9-10, volume: 1, anno: 2001,
pagine: 1743 - 1751
SICI:
1567-5769(200109)1:9-10<1743:MAALPR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACILLUS-CALMETTE-GUERIN; EARLY BCG VACCINATION; MURINE MODEL; ALLERGIC-ASTHMA; GUINEA-PIGS; T-CELLS; INTERLEUKIN-5; INFECTION; HYPERREACTIVITY; INFLAMMATION;
Keywords:
air-way hyperresponsiveness; asthma; Bacillus Calmette-Guerin; Eosinophilia M. vaccae; type 1 T cells; type 2 T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Agrawal, DK Creighton Univ, Sch Med, Ctr Allergy Asthma & Immunol, CRISS 1,Room 131,2500 Calif Plaza, Omaha, NE 68178 USA Creighton Univ CRISS 1,Room131,2500 Calif Plaza Omaha NE USA 68178
Citazione:
M.T. Hopfenspirger et al., "Mycobacterial antigens attenuate late phase response, airway hyperresponsiveness, and bronchoalveolar lavage eosinophilia in a mouse model of bronchial asthma", INT IMMUNO, 1(9-10), 2001, pp. 1743-1751

Abstract

Allergens, in combination with genetic predisposition, drive undifferentiated T cells towards the type 2 T cells. Some childhood infections may activate the production of a type I T cell profile. It is reasonable to speculate that a decrease in childhood infections may increase the incidence of allergy by allowing the immune balance to shift towards the type 2 T cells. Wehypothesized that pre-exposure of mycobacterial antigens in sensitized mice would prevent the development of asthma-like conditions. Specifically. weexamined the effect of mycobacterial antigens, Bacillus Calmette-Guerin (BCG) vaccine and Mycobacterium vaccae, on antigen-induced bronchoconstriction, airway hyperresponsiveness to methacholine, bronchoalveolar lavage eosinophilia, and plasma IL-4 and IL-12 levels in ovalbumin (OVA)-sensitized andchallenged Balb/c mice. Challenge with OVA produced a 2-3-fold increase inbronchoconstriction within 3-5 min, followed by a delayed response after 60 min, the latter of which was significantly attenuated by both BCG and M. vaccae. Airway hyperresponsiveness to methacholine 24 h after OVA challengewas prevented by BCG and M. vaccae. Airway eosinophilia was also preventedby BCG and M. vaccae. The plasma IL-12 levels were significantly increasedand plasma IL-4 levels were significantly decreased following BCG or M. vaccae administration in OVA-sensitized and challenged mice. Interestingly, asignificant increase in plasma IL-12 was observed with BCG as compared to M. vaccae administration, suggesting a stronger type I response to BCG. These data support our hypothesis and suggest that BCG and M. vaccae may prevent the underlying pathophysiological changes in asthma. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:06:05