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Titolo:
Dissimilar behavior of lymph cells in response to the action of aluminum. In vitro and in vivo studies
Autore:
Lauricella, AM; Garbossa, G; Nesse, A;
Indirizzi:
Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, RA-1428 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1428 Aires, DF, Argentina
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 9-10, volume: 1, anno: 2001,
pagine: 1725 - 1732
SICI:
1567-5769(200109)1:9-10<1725:DBOLCI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL RENAL-FUNCTION; ERYTHROLEUKEMIA K562 CELLS; SWISS-WEBSTER MICE; DIALYSIS ENCEPHALOPATHY; ALZHEIMERS-DISEASE; VACCINE ADJUVANTS; HUMAN-LYMPHOCYTES; DIETARY ALUMINUM; PLASMA ALUMINUM; IRON UPTAKE;
Keywords:
aluminum; lymphocytes; immune system; lymphoproliferative response; aluminum toxicity; spleen; lymph nodes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Nesse, A Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Pabellon 2,Piso 4,Ciudad Univ, RA-1428 Buenos Aires, DF, Argentina Univ Buenos Aires Pabellon 2,Piso 4,Ciudad Univ Buenos Aires DF Argentina RA-1428
Citazione:
A.M. Lauricella et al., "Dissimilar behavior of lymph cells in response to the action of aluminum. In vitro and in vivo studies", INT IMMUNO, 1(9-10), 2001, pp. 1725-1732

Abstract

In order to detect possible immunological effects of aluminum (Al) on lymph cells, mice were orally overloaded with pharmacological doses for 22 weeks. The in vitro response of lymph cells to mitogens (phytohemmaglutinin, PHA and concanavaline A, Con A) was examined at the end of the treatment. Thechronic ingestion of Al affected the lymphatic nodes that were found to be2- to 10-fold larger than those of the control mice. Concurrently, the in vitro proliferation of lymphatic node cells was found enhanced, while spleen cell cultures were unaffected. An acute direct action of Al on lymph cells from different sources was also examined. The blastogenic response to PHAof human peripheral lymphocytes was not disturbed by the presence of Al concentrations ranging from 0.09 to 900 muM. However, the response of mouse lymph cells was quite different, given that an Al dose-dependent inhibition was observed for lymphatic node cells, whereas for spleen cells the inhibition was only detected at At concentrations higher than 90 muM. This work shows that At might induce alterations in cell immune responses. The oppositeresults observed in mouse lymphatic node cells after in vitro and in vivo Al treatment, let us suggest that either the stimulating or suppressing effects of At on the immune system might depend on the dose, route of administration and length of exposure, as well as on the cell population assayed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:30:52