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Titolo:
Endemicity, molecular diversity and colonisation routes of Pseudomonas aeruginosa in intensive care units
Autore:
Bertrand, X; Thouverez, M; Talon, D; Boillot, A; Capellier, G; Floriot, C; Helias, JP;
Indirizzi:
CHU Jean Minjoz, Serv Hyg Hosp & Epidemiol Mol, F-25030 Besancon, France CHU Jean Minjoz Besancon France F-25030 ol Mol, F-25030 Besancon, France CHU Jean Minjoz, Serv Reanimat Chirurg, F-25030 Besancon, France CHU Jean Minjoz Besancon France F-25030 hirurg, F-25030 Besancon, France CHU Jean Minjoz, Serv Reanimat Med, F-25030 Besancon, France CHU Jean Minjoz Besancon France F-25030 at Med, F-25030 Besancon, France Ctr Hosp Paul Morel, Serv Reanimat, F-70014 Vesoul, France Ctr Hosp Paul Morel Vesoul France F-70014 animat, F-70014 Vesoul, France Ctr Hosp Gen de Montebeliard, Serv Reanimat, F-25209 Montbeliard, France Ctr Hosp Gen de Montebeliard Montbeliard France F-25209 tbeliard, France
Titolo Testata:
INTENSIVE CARE MEDICINE
fascicolo: 8, volume: 27, anno: 2001,
pagine: 1263 - 1268
SICI:
0342-4642(200108)27:8<1263:EMDACR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIELD GEL-ELECTROPHORESIS; PREDOMINANT PATHOGENS; INFECTIONS; OUTBREAK; COLONIZATION; PNEUMONIA; RISKS;
Keywords:
Pseudomonas aeruginosa; molecular epidemiology; intensive care; colonisation routes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Talon, D CHU Jean Minjoz, Serv Hyg Hosp & Epidemiol Mol, F-25030 Besancon,France CHU Jean Minjoz Besancon France F-25030 -25030 Besancon, France
Citazione:
X. Bertrand et al., "Endemicity, molecular diversity and colonisation routes of Pseudomonas aeruginosa in intensive care units", INTEN CAR M, 27(8), 2001, pp. 1263-1268

Abstract

Objective: We carried out a prospective study to evaluate the endemicity of Pseudomonas aeruginosa in intensive care units (ICUs). Pulsed-field gel electrophoresis (PFGE) was used to determine the genotypes of P. aeruginosa isolates. This allowed us to determine the importance of cross-colonisationand the colonisation routes of P. aeruginosa. Design: We screened epidemiological specimens (rectal swab, nose swab and tracheal aspiration) and routine clinical cultures from patients admitted to ICUs during a 2-year period, from 1st January, 1998, to 31st December, 1999. Setting: The study was carried out in four separate adult ICUs located in the Franche-Comte region of France. These four units admitted a total of 1,500 patients per year. Results: A total of 1686 specimens were collected from 473 patients; 122 of these patients were positive on admission, 351 became positive during hospitalisation. The overall incidence of P aeruginosa was 15.7 cases per 100 patients and 15.1 cases per 1000 days of hospitalisation. Of 184 patients with at least one ICU-acquired positive clinical culture, 104 had been previously identified as carriers by a similar genotype. Typing of 208 non-replicate isolates revealed 101 major DNA patterns. Approximately 50 % of P. aeruginosa carriage or colonisation/infection was acquired via cross-transmission; the other cases probably originated from endogenous sources. Conclusion: Cross-colonisation seems to play an important role in the general spread of P. aeruginosa in ICUs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/08/20 alle ore 23:38:07