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Titolo:
C-14 urea breath test does not predict density of Helicobacter pylori in duodenal ulcer disease
Autore:
Kumar, D; Bal, CS; Dattagupta, S; Ahuja, V; Mathur, M; Sharma, MP;
Indirizzi:
All India Inst Med Sci, Dept Gastroenterol, New Delhi 110029, India All India Inst Med Sci New Delhi India 110029 l, New Delhi 110029, India All India Inst Med Sci, Dept Nucl Med, New Delhi 110029, India All India Inst Med Sci New Delhi India 110029 d, New Delhi 110029, India All India Inst Med Sci, Dept Pathol, New Delhi 110029, India All India Inst Med Sci New Delhi India 110029 l, New Delhi 110029, India
Titolo Testata:
INDIAN JOURNAL OF MEDICAL RESEARCH
, volume: 113, anno: 2001,
pagine: 129 - 134
SICI:
0971-5916(200104)113:<129:CUBTDN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFECTION; GASTRITIS; HISTOLOGY; CULTURE; INFLAMMATION; ERADICATION; PREVALENCE;
Keywords:
density; duodenal ulcer; Helicobacter pylori; urea breath test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sharma, MP All India Inst Med Sci, Dept Gastroenterol, New Delhi 110029, India All India Inst Med Sci New Delhi India 110029 i 110029, India
Citazione:
D. Kumar et al., "C-14 urea breath test does not predict density of Helicobacter pylori in duodenal ulcer disease", I J MED RES, 113, 2001, pp. 129-134

Abstract

Background & objectives: The density of Helicobacter pylori in the gastricmucosa has prognostic significance, higher densities being associated withgreater chances of development of duodenal ulcer and chronic atrophic gastritis as well as poor eradication by drug therapy. The aim of this study was to assess if C-14-urea breath test counts reflect bacterial density. Methods: Sixty patients with endoscopically proven active duodenal ulcer and H. pylori positivity as determined by rapid urease test and gastric histology were studied. Gastric antral and corpus biopsies were graded for chronic gastritis, activity (presence of polymorphonuclear cells) and bacterialdensity (at surface and in pits) based on the Sydney system on a scale of four grades ranging from 0 to 3 (absent, mild, moderate and severe). C-14 urea breath test was performed in all the patients. Results: Chronic gastritis as well as activity was more prevalent as well as severe in the antrum as compared to the corpus. H. pylori density was also significantly more in the antrum as compared to the corpus both at the surface as well as in the pits. H. pylori density correlated with the grade of chronic gastritis and activity both in the antrum and in the corpus. Urea breath test counts ranged from 331.3 cpm (counts per minute) to 8770.5 cpm and these did not correlate with histological H. pylori density at any ofthe sites. Interpretation & conclusions: 14C urea breath test does not reflect H. pylori density on histology in patients of duodenal ulcer disease.

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Documento generato il 09/07/20 alle ore 01:27:14