Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
High level of anticholesterol antibodies (ACHA) in HIV patients. Normalization of serum ACHA concentration after introduction of HAART
Autore:
Horvath, A; Banhegyi, D; Biro, A; Ujhelyi, E; Veres, A; Horvath, L; Prohaszka, Z; Bacsi, A; Tarjan, V; Romics, L; Horvath, I; Toth, FD; Fust, G; Karadi, I;
Indirizzi:
Semmelweis Univ Med, Fac Med, Dept Internal Med 3, H-1125 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1125 3, H-1125 Budapest, Hungary Hungarian Acad Sci, Res Grp Metab Genet & Immunol, Budapest, Hungary Hungarian Acad Sci Budapest Hungary Genet & Immunol, Budapest, Hungary St Laszlo Hosp, Dept Immunol, Budapest, Hungary St Laszlo Hosp Budapest Hungary o Hosp, Dept Immunol, Budapest, Hungary Debrecen Univ Med, Med & Hlth Sci Ctr, Inst Microbiol, Debrecen, Hungary Debrecen Univ Med Debrecen Hungary r, Inst Microbiol, Debrecen, Hungary Natl Transfus Serv, AIDS Lab, Budapest, Hungary Natl Transfus Serv Budapest Hungary s Serv, AIDS Lab, Budapest, Hungary Natl Inst Dermatol & Venerol, Budapest, Hungary Natl Inst Dermatol & Venerol Budapest Hungary enerol, Budapest, Hungary
Titolo Testata:
IMMUNOBIOLOGY
fascicolo: 5, volume: 203, anno: 2001,
pagine: 756 - 768
SICI:
0171-2985(200108)203:5<756:HLOAA(>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; INFECTION; CHOLESTEROL; AUTOANTIBODIES; LIPIDS; HYPERTRIGLYCERIDEMIA; LIPOPROTEINS; INDIVIDUALS; METABOLISM; INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Fust, G Semmelweis Univ Med, Fac Med, Dept Internal Med 3, Kutvolgyi Ut 4,H-1125 Budapest, Hungary Semmelweis Univ Med Kutvolgyi Ut 4 Budapest Hungary H-1125 ungary
Citazione:
A. Horvath et al., "High level of anticholesterol antibodies (ACHA) in HIV patients. Normalization of serum ACHA concentration after introduction of HAART", IMMUNOBIOL, 203(5), 2001, pp. 756-768

Abstract

Anticholesterol antibodies (ACHA) are natural antibodies against the 3 beta -OH group of cholesterol. Since lipid disorders are common in HIV infection and HAART may further enhance dislipidaemia, we determined by using an ELISA method serum ACHA concentrations in HIV patients and healthy HIV-seronegative controls. ACHA levels were almost 4 times higher in the sera of 46 patients than in 110 controls. No difference in the specificity of ACHA was found between HIV-seropositive and HIV-sero negative sera. Binding of ACI-IA to cholesterol-coated plates from a HIV-seropositive serum was dose-dependently inhibitedby preincubation with HIV-1(BA-L) preparation. Serum concentration of ACHAwas significantly higher in the patients with low serum cholesterol levelsthan in those with normal cholesterol levels. HAART induced a marked drop of ACHA concentration. We found a significant negative correlation between the length of HAART and the ACHA levels. By contrast, HAART did not significantly influence total IgG concentration and titers of antibodies against 60 kD heat shock protein. Our findings indicate that high levels of ACHA in HIV-infection may contribute to the development, of hypocholesterolaemia frequently observed in this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:42:29