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Titolo:
Linkage and association to candidate regions in Swedish atopic dermatitis families
Autore:
Soderhall, C; Bradley, M; Kockum, I; Wahlgren, CF; Luthman, H; Nordenskjold, M;
Indirizzi:
Karolinska Inst, CMM 02, Dept Mol Med, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 ed, SE-17176 Stockholm, Sweden Karolinska Inst, Karolinska Hosp, Dept Dermatol & Venereol, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 reol, S-10401 Stockholm, Sweden
Titolo Testata:
HUMAN GENETICS
fascicolo: 2, volume: 109, anno: 2001,
pagine: 129 - 135
SICI:
0340-6717(200108)109:2<129:LAATCR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENOME-WIDE SEARCH; MAST-CELL CHYMASE; PARTY DIAGNOSTIC-CRITERIA; AFFINITY IGE RECEPTOR; NECROSIS-FACTOR-ALPHA; FC-EPSILON-RI; CHROMOSOME 11Q13; FOUNDER POPULATION; UNDERLYING ASTHMA; JAPANESE FAMILIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Soderhall, C Karolinska Inst, CMM 02, Dept Mol Med, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 Stockholm, Sweden
Citazione:
C. Soderhall et al., "Linkage and association to candidate regions in Swedish atopic dermatitis families", HUM GENET, 109(2), 2001, pp. 129-135

Abstract

We have studied, in 406 families with at least two siblings affected with atopic dermatitis (in total 1514 individuals) from the Swedish population, linkage and association to five chromosomal regions (2q35, 5q31-33, 6p21, 11q13 and 14q11) previously implicated in atopic diseases. The region on 14q11 gave evidence for linkage to atopic dermatitis (NPL-score: 2.36, P<0.009). In the 11q13 region, there was a clear association to an intragenic marker in the <beta>-subunit of the high-affinity IgE receptor for raised allergen-specific serum IgE levels (P<0.009). When a quantitative variable for the severity of atopic dermatitis was studied, evidence was found in favour of linkage to the 5q31-33 region, with the highest Z-score (2.06) close to the marker D5S458 (P<0.005).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:54:56