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Titolo:
Trichloroethylene carcinogenic potency
Autore:
Willhite, CC;
Indirizzi:
State Calif, Dept Tox Subst Control, Berkeley, CA 94710 USA State Calif Berkeley CA USA 94710 x Subst Control, Berkeley, CA 94710 USA
Titolo Testata:
HUMAN AND ECOLOGICAL RISK ASSESSMENT
fascicolo: 4, volume: 7, anno: 2001,
pagine: 767 - 777
SICI:
1080-7039(200108)7:4<767:TCP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-CELL CANCER; RETROSPECTIVE COHORT MORTALITY; AIRCRAFT MAINTENANCE FACILITY; FORMIC-ACID EXCRETION; OCCUPATIONAL EXPOSURE; SPECIES-DIFFERENCES; MOUSE-LIVER; WORKERS; RISK; METABOLISM;
Keywords:
weight-of-evidence; trichloroethylene; human cancer risk; cancer potency derivation; science policy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Willhite, CC State Calif, Dept Tox Subst Control, 700 Heinz St,Suite 200, Berkeley, CA 94710 USA State Calif 700 Heinz St,Suite 200 Berkeley CA USA 94710 USA
Citazione:
C.C. Willhite, "Trichloroethylene carcinogenic potency", HUM ECOL R, 7(4), 2001, pp. 767-777

Abstract

Current U.S. regulatory policy regarding the carcinogenic potential of trichloroethylene (TCE) in humans is conflicting. Weight-of-evidence considerations show either no or inconsistent associations between chronic TCE exposure and excess human cancer risk. Occupational exposure limits are so great(538,000 mug/m(3)) that daily absorbed doses are greater than the rodent no observed adverse effect level (NOAEL). Using the regulatory strength-of-evidence approach, recommended ambient air concentration limits (1.1 mug/m(3)) are derived using the default linearized multistage model. The latter assumes a radiomimetic mode of action, a highly questionable assumption in light of published TCE mechanism of action data. Given the current state of U. S. regulatory policy on this material, credible analyses of the data are needed from neutral nongovernmental organizations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:31:58