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Titolo:
Classical and nonclassical estrogen action in the developing midbrain
Autore:
Kuppers, E; Ivanova, T; Karolczak, M; Lazarov, N; Fohr, K; Beyer, C;
Indirizzi:
Univ Ulm, D-89069 Ulm, Germany Univ Ulm Ulm Germany D-89069Univ Ulm, D-89069 Ulm, Germany Thracian Univ, BG-6003 Stara Zagora, Bulgaria Thracian Univ Stara ZagoraBulgaria BG-6003 -6003 Stara Zagora, Bulgaria
Titolo Testata:
HORMONES AND BEHAVIOR
fascicolo: 2, volume: 40, anno: 2001,
pagine: 196 - 202
SICI:
0018-506X(200109)40:2<196:CANEAI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; SEX-DIFFERENCES; DOPAMINERGIC-NEURONS; STRIATAL DOPAMINE; STEROIDS; BRAIN; ESTRADIOL; RECEPTOR; RAT; MESENCEPHALON;
Keywords:
estrogen; estrogen receptors; dopamine; midbrain; TH; neurite growth; signaling; ion channels; calcium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Beyer, C Univ Ulm, D-89069 Ulm, Germany Univ Ulm Ulm Germany D-89069Univ Ulm, D-89069 Ulm, Germany
Citazione:
E. Kuppers et al., "Classical and nonclassical estrogen action in the developing midbrain", HORMONE BEH, 40(2), 2001, pp. 196-202

Abstract

There is widespread acceptance that estrogen is involved in various steps of cellular differentiation during brain development. In the past years, wehave demonstrated such a developmental role for estrogen in the rodent midbrain. Precisely, estrogen affects midbrain dopamine neurons with respect to functional and morphological maturation. On the cellular level, estrogen may act classically by binding and activating its respective nuclear receptors, thereby controlling the transcription of target genes. On the other hand, many estrogen effects in the CNS are transmitted nonclassically by interactions with putative membrane receptors and by stimulating distinct intracellular signaling cascades. In the midbrain, classical and nonclassical estrogen signaling routes operate side by side to ensure the proper development of dopaminergic cells. In the present report, we detail some of the cellular and molecular events which are activated by estrogen and are thought to take part in the estrogen-mediated stimulation of dopamine neuron differentiation. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:22:25