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Titolo:
A predictive model for regulatory sequences directing liver-specific transcription
Autore:
Krivan, W; Wasserman, WW;
Indirizzi:
Karolinska Inst, Ctr Genom & Bioinformat, Bioinformat Unit, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Unit, S-17177 Stockholm, Sweden
Titolo Testata:
GENOME RESEARCH
fascicolo: 9, volume: 11, anno: 2001,
pagine: 1559 - 1566
SICI:
1088-9051(200109)11:9<1559:APMFRS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCYTE NUCLEAR FACTOR-1; BINDING-SITES; INFORMATION-CONTENT; GENE-EXPRESSION; PROMOTER; REGIONS; IDENTIFICATION; GENOME; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Wasserman, WW Karolinska Inst, Ctr Genom & Bioinformat, Bioinformat Unit, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Stockholm, Sweden
Citazione:
W. Krivan e W.W. Wasserman, "A predictive model for regulatory sequences directing liver-specific transcription", GENOME RES, 11(9), 2001, pp. 1559-1566

Abstract

The identification and interpretation of the regulatory signals within thehuman genome remain among the greatest goals and most difficult challengesgenome analysis. The ability to predict the temporal and spatial control of transcription is likely to require a combination of methods to address the contribution of sequence-specific signals, protein-protein interactions and chromatin structure. We present here a new procedure to identify clusters of transcription factor binding sites characteristic of sequence modules experimentally verified to direct transcription selectively to liver cells. This algorithm is sufficiently specific to identify known regulatory sequences in genes selectively expressed in liver, promising acceleration of experimental promoter analysis. In combination with phylogenetic footprinting.this improvement in the specificity of predictions is sufficient to motivate a scan of the human genome. Potential regulatory modules were identifiedill orthologous human and rodent genomic sequences containing both known and uncharacterized genes.

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Documento generato il 18/01/20 alle ore 01:42:00