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Titolo:
Drosophila euchromatic LTR retrotransposons are much younger than the hostspecies in which they reside
Autore:
Bowen, NJ; McDonald, JF;
Indirizzi:
Univ Georgia, Dept Genet, Athens, GA 30602 USA Univ Georgia Athens GA USA30602 eorgia, Dept Genet, Athens, GA 30602 USA
Titolo Testata:
GENOME RESEARCH
fascicolo: 9, volume: 11, anno: 2001,
pagine: 1527 - 1540
SICI:
1088-9051(200109)11:9<1527:DELRAM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROMYCES-CEREVISIAE GENOME; LONG TERMINAL REPEAT; TRANSPOSABLE ELEMENTS; ENDOGENOUS RETROVIRUS; MELANOGASTER SUBGROUP; DNA LOSS; EVOLUTION; SEQUENCE; GENE; DATABASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: McDonald, JF Univ Georgia, Dept Genet, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 Genet, Athens, GA 30602 USA
Citazione:
N.J. Bowen e J.F. McDonald, "Drosophila euchromatic LTR retrotransposons are much younger than the hostspecies in which they reside", GENOME RES, 11(9), 2001, pp. 1527-1540

Abstract

The recent release of the complete euchromatic genome sequence of Drosophila melanogaster offers a unique opportunity to explore the evolutionary history of transposable elements (TEs) within the genome of a higher eukaryote. In tills report, we describe the annotation and phylogenetic comparison of 178 full-length long terminal repeat (LTR) retrotransposons from the sequenced component of the D. melanogaster genome. We report the characterization of 17 LTR retrotransposon families described previously and five newly discovered element families. Phylogenetically, these families can be dividedinto three distinct lineages that consist of members from the canonical Copia and Gypsy groups as well as a newly discovered third group containing BEL, mazi, and roo elements. Each family consists of members with average pairwise identities greater than or equal to 99% at the nucleotide level, indicating they may be the products of recent transposition events. Consistentwith the recent transposition hypothesis, we found that 70% (125/178) of the elements (across all families) have identical intra-element LTRs. Using the synonymous substitution rate that has been calculated previously for Drosophila (.016 substitutions per site per million years) and the intra-element LTR divergence calculated here, the average age of the remaining 30% (53/178) of the elements was found to be 137,000 +/- 89,000 yr. Collectively,these results indicate that many full-length LTR retrotransposons present in the D. melanogaster genome have transposed well after this species diverged from its closest relative Drosophila simulans, 2.3 +/- .3 million yearsago.

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Documento generato il 27/09/20 alle ore 13:38:51