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Titolo:
Favorable attitudes toward testing for chromosomal abnormalities via analysis of fetal cells in maternal blood
Autore:
Zamerowski, ST; Lumley, MA; Arreola, RA; Dukes, K; Sullivan, L;
Indirizzi:
Villanova Univ, Villanova, PA 19085 USA Villanova Univ Villanova PA USA 19085 anova Univ, Villanova, PA 19085 USA Wayne State Univ, Detroit, MI USA Wayne State Univ Detroit MI USAWayne State Univ, Detroit, MI USA Univ Tennessee, Hlth Sci Ctr, Knoxville, TN 37996 USA Univ Tennessee Knoxville TN USA 37996 th Sci Ctr, Knoxville, TN 37996 USA DM STAT Inc, Boston, MA USA DM STAT Inc Boston MA USADM STAT Inc, Boston, MA USA Boston Univ, Boston, MA 02215 USA Boston Univ Boston MA USA 02215Boston Univ, Boston, MA 02215 USA
Titolo Testata:
GENETICS IN MEDICINE
fascicolo: 4, volume: 3, anno: 2001,
pagine: 301 - 309
SICI:
1098-3600(200107/08)3:4<301:FATTFC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRENATAL-DIAGNOSIS; DECISION-ANALYSIS; PREGNANT-WOMEN; DOWN-SYNDROME; ANXIETY; AMNIOCENTESIS; ACCEPTABILITY; INFORMATION; KNOWLEDGE;
Keywords:
prenatal diagnosis; maternal blood analysis; serum screening; fetal cells; attitudes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Zamerowski, ST Villanova Univ, Villanova, PA 19085 USA Villanova Univ Villanova PA USA 19085 lanova, PA 19085 USA
Citazione:
S.T. Zamerowski et al., "Favorable attitudes toward testing for chromosomal abnormalities via analysis of fetal cells in maternal blood", GENET MED, 3(4), 2001, pp. 301-309

Abstract

Purpose: The NICHD Fetal Cell Isolation Study (NIFTY) was a multicentered project to isolate fetal cells from maternal blood to detect fetal chromosomal abnormalities. The project included a psychosocial component, which is the basis of this article. We examined the attitudes of high-risk pregnant women toward the availability of a maternal blood test to identify fetal chromosomal abnormalities, how women would respond to hypothetical normal andabnormal maternal blood testing results, and the factors associated with awoman's preference to have an invasive procedure in response to a normal maternal blood test. Methods: High-risk pregnant women (N = 854) planning tohave prenatal diagnostic invasive testing (amniocentesis or chorionic villus sampling) completed a survey. Results: The women highly favored maternalblood testing. Almost ail women would seek invasive testing after an abnormal blood test. Only half of the women would seek invasive testing after a normal blood test; these women were older, more willing to terminate their pregnancy, and valued the increased accuracy of invasive testing more highly than women who would not have invasive testing after a normal maternal blood test. Conclusions: Women having invasive diagnostic testing welcome a noninvasive procedure that uses fetal cells in maternal blood, and its availability would decrease invasive testing by approximately 50%. Research needs to examine the attitudes and anticipated responses of other risk groups as well as the effects of information about maternal blood test sensitivity and specificity on attitudes and responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:29:33