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Titolo:
Identification of chromosomal deficiencies that modify Drosophila mastermind mutant phenotypes
Autore:
Yedvobnick, B; Helms, W; Barrett, B;
Indirizzi:
Emory Univ, Dept Biol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ry Univ, Dept Biol, Atlanta, GA 30322 USA
Titolo Testata:
GENESIS
fascicolo: 4, volume: 30, anno: 2001,
pagine: 250 - 258
SICI:
1526-954X(200108)30:4<250:IOCDTM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-PROTEIN; WING MARGIN; GENE MASTERMIND; NOTCH; EXPRESSION; DOWNSTREAM; LOCUS; CUT; MELANOGASTER; ACTIVATION;
Keywords:
mastermind; notch pathway; Drosophila; genetic screen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Yedvobnick, B Emory Univ, Dept Biol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Biol, Atlanta, GA 30322 USA
Citazione:
B. Yedvobnick et al., "Identification of chromosomal deficiencies that modify Drosophila mastermind mutant phenotypes", GENESIS, 30(4), 2001, pp. 250-258

Abstract

Mastermind (Mam) is a component of Notch pathway signaling. In combinationwith the intracellular domain of Notch and Suppressor of Hairless, Mam forms a transcriptional activation complex. We have initiated a genetic approach to identify other loci involved in Mam function. The screen utilizes engineered mutations in Mam that derive from GAL4-UAS-directed expression of dominant negative constructs. When driven at the wing margin, truncated versions of Mam phenocopy Notch pathway mutations. Correlated with these phenotypes is depression of Notch pathway target expression. Strains expressing truncated versions of Mam were tested for genetic interactions with a large collection of chromosomal deficiencies. Genomic segments that enhanced and suppressed the dominant wing phenotype were identified. These regions may contain uncharacterized loci involved in Notch pathway function. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 04/04/20 alle ore 09:03:16