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Titolo:
Sensorimotor gating deficits and hypofrontality in schizophrenia
Autore:
Hazlett, EA; Buchsbaum, MS;
Indirizzi:
Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA Mt Sinai Sch Med New York NY USA 10029 t Psychiat, New York, NY 10029 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D1069 - D1072
SICI:
1093-9946(200109)6:<D1069:SGDAHI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; GLUCOSE-METABOLISM; ABNORMALITIES;
Keywords:
sensorimotor gating; prepulse inhibition; startle eyeblink modification; schizophrenia; positron emission tomography; frontal lobe; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hazlett, EA Mt Sinai Sch Med, Dept Psychiat, Box 1505,1 Gustave L Levy Pl,New York, NY 10029 USA Mt Sinai Sch Med Box 1505,1 Gustave L Levy Pl New York NY USA 10029
Citazione:
E.A. Hazlett e M.S. Buchsbaum, "Sensorimotor gating deficits and hypofrontality in schizophrenia", FRONT BIOSC, 6, 2001, pp. D1069-D1072

Abstract

Patients with schizophrenia exhibit (a) deficient sensorimotor gating as indexed by impaired prepulse inhibition (PPI) of the startle eyeblink reflexsuggesting abnormal automatic information processing and (b) abnormal attentional modulation of PPI suggesting impaired controlled information processing. Here we test the hypothesis of deficient attentional modulation of PPI in schizophrenia as a defect in the interrelationship between frontal lobe functions of planning and executive action and posterior function of processing of sensory stimulation using positron emission tomography (PET). Consistent with the literature, our findings indicate that unmedicated schizophrenia patients exhibit lower frontal/occipital ratios (termed "hypofrontality") compared with healthy controls (n=15 in each group) during a standardtone-length-judgment (attention-to-prepulse) task. Moreover, better attentional modulation of PPI was associated with higher frontal/occipital ratiosin the control, but not the patient group. These findings extend animal models to humans by demonstrating the importance of frontal and occipital lobe coordination in the modulation of PPI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:02:34