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Titolo:
N-1-acetyl-N-2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant
Autore:
Tan, DX; Manchester, LC; Burkhardt, S; Sainz, RM; Mayo, JC; Kohen, R; Shohami, E; Huo, YS; Hardeland, R; Reiter, RJ;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 truct Biol, San Antonio, TX 78229 USA Univ Gottingen, D-37073 Gottingen, Germany Univ Gottingen Gottingen Germany D-37073 gen, D-37073 Gottingen, Germany Antropol Inst Zool, D-37073 Gottingen, Germany Antropol Inst Zool Gottingen Germany D-37073 D-37073 Gottingen, Germany Hebrew Univ Jerusalem, David R Bloom Ctr Pharm, Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel oom Ctr Pharm, Jerusalem, Israel
Titolo Testata:
FASEB JOURNAL
fascicolo: 10, volume: 15, anno: 2001,
pagine: NIL_75 - NIL_90
SICI:
0892-6638(200108)15:10<NIL_75:NABAAM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC VOLTAMMETRY; OXIDATIVE DAMAGE; IN-VITRO; PROTECTION; CAPACITY; DEATH; CELLS; RATS; SYSTEM; SERUM;
Keywords:
cyclic voltammetry; glutamate; amyloid beta-peptide; hydrogen peroxide; 8-hydroxydeoxyguanosine; lipid peroxidation; free radical; neuron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Reiter, RJ Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, Mail Code 7762,7703Floyd Curl Dr, San Antonio, TX 78229 USA Univ Texas Mail Code 7762,7703 Floyd Curl Dr San Antonio TX USA 78229
Citazione:
D.X. Tan et al., "N-1-acetyl-N-2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant", FASEB J, 15(10), 2001, pp. NIL_75-NIL_90

Abstract

The biogenic amine N-1-acetyl-N-2-formyl-5-methoxykynuramine (AFMK) was investigated for its potential antioxidative capacity. AFMK is a metabolite generated through either an enzymatic or a chemical reaction pathway from melatonin. The physiological function of AFMK remains unknown. To our knowledge, this report is the first to document the potent antioxidant action of this biogenic amine. Cyclic voltammetry (CV) shows that AFMK donates two electrons at potentials of 456 mV and 668 mV, and therefore it functions as a reductive force. This function contrasts with all other physiological antioxidants that donate a single electron only when they neutralize free radicals. AFMK reduced 8-hydroxydeoxyguanosine formation induced by the incubation of DNA with oxidants significantly. Lipid peroxidation resulting from free radical damage to rat liver homogenates was also prevented by the addition of AFMK. The inhibitory effects of AFMK on both DNA and lipid damage appear to be dose-response related. In cell culture, AFMK efficiently reduced hippocampal neuronal death induced by either hydrogen peroxide, glutamate, or amyloid beta (25-35) peptide. AFMK is a naturally occurring molecule withpotent free radical scavenging capacity (donating two electrons/molecule) and thus may be a valuable new antioxidant for preventing and treating freeradical-related disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:49:27