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Titolo:
Preferential transduction of neurons by canine adenovirus vectors and their efficient retrograde transport in vivo
Autore:
Soudais, C; Laplace-Builhe, C; Kissa, K; Kremer, EJ;
Indirizzi:
Genethon III, CNRS, URA 1923, F-91002 Evry, France Genethon III Evry France F-91002 I, CNRS, URA 1923, F-91002 Evry, France Inst Pasteur, Paris, France Inst Pasteur Paris FranceInst Pasteur, Paris, France Inst Genet Mol Montpellier, CNRS, UMR 5535, F-34293 Montpellier 5, France Inst Genet Mol Montpellier Montpellier France 5 93 Montpellier 5, France
Titolo Testata:
FASEB JOURNAL
fascicolo: 10, volume: 15, anno: 2001,
pagine: NIL_35 - NIL_57
SICI:
0892-6638(200108)15:10<NIL_35:PTONBC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MEDIATED GENE-TRANSFER; COLI BETA-GALACTOSIDASE; VIRAL CODING SEQUENCES; LONG-TERM; NEUROTROPHIC FACTOR; BRAIN INFLAMMATION; RECEPTOR PROTEIN; IMMUNE-RESPONSES; SKELETAL-MUSCLE;
Keywords:
canine adenovirus; neurons; retrograde axonal transport; neurodegenerative diseases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Kremer, EJ Genethon III, CNRS, URA 1923, 1Bis,Rue Int, F-91002 Evry, France Genethon III 1Bis,Rue Int Evry France F-91002 002 Evry, France
Citazione:
C. Soudais et al., "Preferential transduction of neurons by canine adenovirus vectors and their efficient retrograde transport in vivo", FASEB J, 15(10), 2001, pp. NIL_35-NIL_57

Abstract

In the central nervous system (CNS), there are innate obstacles to the modification of neurons: their relative low abundance versus glia and oligodendrocytes, the inaccessibility of certain target populations, and the volumeone can inject safely. Our aim in this study was to characterize the in vivo efficacy of a novel viral vector derived from a canine adenovirus (CAV-2). Here we show that CAV-2 preferentially transduced i) rat olfactory sensory neurons; ii) rodent CNS neurons in vitro and in vivo; and, more clinically relevant, iii) neurons in organotypic slices of human cortical brain. CAV-2 also showed a high disposition for retrograde axonal transport in vivo. We examined the molecular basis of neuronal targeting by CAV-2 and suggestthat due to CAR (coxsackie adenovirus receptor) expression on neuronal cells-and not oligodendrocytes, glia, myofibers, and nasal epithelial cells-CAV-2 vectors transduced neurons preferentially in these diverse tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:59:19