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Titolo:
Role of probiotics in inflammatory bowel disease and intestinal infections
Autore:
Gionchetti, P; Amadini, C; Rizzello, F; Venturi, A; Romagnoli, R; Palmonari, V; De Simone, C; Campieri, M;
Indirizzi:
Univ Bologna, Policlin S Orsola, Dept Internal Med, I-40138 Bologna, ItalyUniv Bologna Bologna Italy I-40138 Internal Med, I-40138 Bologna, Italy
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 8, volume: 11, anno: 2001,
pagine: 1277 - 1283
SICI:
1354-3776(200108)11:8<1277:ROPIIB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROHNS-DISEASE; ULCERATIVE-COLITIS; MAINTENANCE TREATMENT; ESCHERICHIA-COLI; CHRONIC POUCHITIS; DOUBLE-BLIND; OAT FIBER; FLORA; BACTERIA; MESALAZINE;
Keywords:
inflammatory bowel disease (IBD); infective diarrhoea; intestinal microflora; pouchitis; probiotics;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Gionchetti, P Univ Bologna, Policlin S Orsola, Dept Internal Med, Via Massarenti 9, I-40138 Bologna, Italy Univ Bologna Via Massarenti 9 Bologna Italy I-40138 , Italy
Citazione:
P. Gionchetti et al., "Role of probiotics in inflammatory bowel disease and intestinal infections", EXPERT OP T, 11(8), 2001, pp. 1277-1283

Abstract

Bacteria are present throughout the GI tract but their pattern and concentrations vary greatly. Probiotics are living microorganisms that belong to the normal intestinal flora and are important to the health and well-being of the host. The concept of probiotic therapy is still controversial; there are many data from in vitro and animal studies, however, to date the beneficial effects of probiotics in humans have mostly been demonstrated under poorly defined experimental conditions. Several experimental and clinical observations suggest a role for the intestinal microflora in inflammatory bowel disease (IBD) pathogenesis and there is increasing evidence supporting the potential therapeutic role for probiotics in the treatment of IBD. The use of probiotics to treat GI infections has produced contrasting results; their efficacy in the prevention or treatment of infective diarrhoea was evaluated in a large number of studies; however, the most convincing evidence of their benefit concerns rotavirus infection in children. Future research needs to focus on obtaining more precise information on the composition of the enteric microflora and the mechanisms of action of probiotics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:50:37