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Titolo:
Novel biomaterials for drug delivery
Autore:
Luo, Y; Prestwich, GD;
Indirizzi:
Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 Chem, Salt Lake City, UT 84112 USA
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 9, volume: 11, anno: 2001,
pagine: 1395 - 1410
SICI:
1354-3776(200109)11:9<1395:NBFDD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GROWTH-HORMONE; CALCIUM-PHOSPHATE BIOMATERIAL; LACTIDE-CO-GLYCOLIDE; CONTROLLED-RELEASE; IN-VITRO; BIODEGRADABLE MICROSPHERES; HYDROLYTIC DEGRADATION; POLY(ETHYLENE GLYCOL); BLOCK-COPOLYMERS; POLYMERIC DRUGS;
Keywords:
biodegradable; biomaterials; drug delivery; hybrid; inorganic; natural; polymer; synthetic;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
130
Recensione:
Indirizzi per estratti:
Indirizzo: Prestwich, GD Univ Utah, Dept Med Chem, 30 South 2000 East,Room 201, Salt Lake City, UT 84112 USA Univ Utah 30 South 2000 East,Room 201 Salt Lake City UT USA 84112
Citazione:
Y. Luo e G.D. Prestwich, "Novel biomaterials for drug delivery", EXPERT OP T, 11(9), 2001, pp. 1395-1410

Abstract

Safety and efficacy of pharmaceutical agents can be greatly improved by encapsulation within, or covalent attachment to, a biomaterial carrier. Such drug delivery systems differ from conventional drug dosage forms (pills, tablets, ointments, creams, injectables and 'tiny time capsules') in that a localised depot of drug provides patterned release of the active agent with a predetermined time course. The pattern of drug release may be constant, oscillating, declining continuously, or even pulsatile. The need to engineerdifferent release patterns for drugs of different molecular sizes, potency, stability and hydrophobicity provides the impetus for active study of thedesign of new biomaterials, intelligent delivery systems and approaches for delivery through different portals in the body. The field of controlled drug delivery provides a driving force for current innovations in biomaterials. For most drug delivery systems, polymers function simply as inert, biocompatible carriers. In other systems, polymers can be designed with targeting or pathology-responsive functions. This review summarises some of the recently developed intellectual property in the field of biomaterials appliedto drug delivery systems. Included are implantable ceramics and other inorganic materials, nondegradable and degradable synthetic polymers, natural polymers and hybrid biomaterials derived from synthetic and natural polymers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:45:42