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Titolo:
Lung clearance in children with Duchenne muscular dystrophy or spinal muscular atrophy with and without CPAP (continuous positive airway pressure)
Autore:
Klefbeck, B; Svartengren, K; Camner, P; Philipson, K; Svartengren, M; Sejersen, T; Mattsson, E;
Indirizzi:
Karolinska Inst, Div Occupat Med, Dept Publ Hlth Sci, Stockholm, Sweden Karolinska Inst Stockholm Sweden Dept Publ Hlth Sci, Stockholm, Sweden Karolinska Inst, Div Inhalat Toxicol, Inst Environm Med, Stockholm, SwedenKarolinska Inst Stockholm Sweden , Inst Environm Med, Stockholm, Sweden Sweden Karolinska Inst, Stockholm, Sweden Sweden Karolinska Inst Stockholm Sweden olinska Inst, Stockholm, Sweden Karolinska Inst, Dept Woman & Child Hlth, Dept Cell & Mol Biol, Stockholm,Sweden Karolinska Inst Stockholm Sweden Dept Cell & Mol Biol, Stockholm,Sweden Karolinska Inst, Dept Phys Therapy, Stockholm, Sweden Karolinska Inst Stockholm Sweden , Dept Phys Therapy, Stockholm, Sweden
Titolo Testata:
EXPERIMENTAL LUNG RESEARCH
fascicolo: 6, volume: 27, anno: 2001,
pagine: 469 - 484
SICI:
0190-2148(200109)27:6<469:LCICWD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL CILIATED AIRWAYS; PARTICLES; DEPOSITION; ATELECTASIS; VENTILATION; MANAGEMENT; RETENTION; THERAPY; 6-MU-M; STAGE;
Keywords:
children; CPAP; lung clearance; neuromuscular diseases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Klefbeck, B Karolinska Inst, Dept Phys Therapy, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 157 Huddinge, Sweden
Citazione:
B. Klefbeck et al., "Lung clearance in children with Duchenne muscular dystrophy or spinal muscular atrophy with and without CPAP (continuous positive airway pressure)", EXP LUNG R, 27(6), 2001, pp. 469-484

Abstract

Bronchiolar clearance was studied in 7 boys in the age range of 8 to 17 years, 6 with Duchenne muscular dystrophy (DMD) and I with spinal muscular atrophy type II (SMA-II). These boys had healthy lungs but a severely reducedmuscular strength (wheelchair dependent). In 6 of the boys, clearance was studied twice, at one occasion as a control and at the other occasion following treatment with continuous positive airway pressure (CPAP). A control group of healthy adults was used. In the clearance examinations, 6-mum Teflon particles, labeled with In-111 was inhaled extremely slowly, 0.05 L/s. This gives a deposition mainly in the bronchioles. Lung retention was measured after 0, 24, 48, and 72 hours. A model for deposition of particles in theadult lung was scaled down to represent the children in this study. Deposition in various airway generations was calculated to be similar in childrenand adults. Also the measured retentions were similar in the boys and the adults. In the clearance experiments during CPAP treatment, there was a significantly lower retention after 72 hours (but not after 24 and 48 hours) than in the control experiments. The results indicate that a severe reduction of muscular strength, and thereby a reduction of mechanical Movement of the lung, does not affect clearance from large and small airways. However, some effect of clearance from, small airways cannot be excluded due to the short measuring period. The small but significant effect of the CPAP treatment might have potential clinical importance and suggest that bronchiolar clearance can be affected by some form of mechanical force.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:36:53