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Titolo:
Differential patterns of performance impairment result from changed reinforcer efficacy or distracting stimulation in a two-choice rodent spatial signal detection task
Autore:
Mao, JB; Kanhai, G; Moglia, D; Robinson, JK;
Indirizzi:
SUNY Stony Brook, Dept Psychol, Stony Brook, NY 11994 USA SUNY Stony Brook Stony Brook NY USA 11994 chol, Stony Brook, NY 11994 USA SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11994 USA SUNY Stony Brook Stony Brook NY USA 11994 ehav, Stony Brook, NY 11994 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 426, anno: 2001,
pagine: 55 - 63
SICI:
0014-2999(20010824)426:1-2<55:DPOPIR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-INDUCED LESIONS; SUSTAINED ATTENTION; VISUAL-DISCRIMINATION; SUBSTANTIA INNOMINATA; ANIMAL-MODEL; MK-801; RATS; SCHIZOPHRENIA; DIZOCILPINE; SCOPOLAMINE;
Keywords:
attention; sustained; MK-801; motivation; signal detection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Robinson, JK SUNY Stony Brook, Dept Psychol, Stony Brook, NY 11994 USA SUNY Stony Brook Stony Brook NY USA 11994 rook, NY 11994 USA
Citazione:
J.B. Mao et al., "Differential patterns of performance impairment result from changed reinforcer efficacy or distracting stimulation in a two-choice rodent spatial signal detection task", EUR J PHARM, 426(1-2), 2001, pp. 55-63

Abstract

Measures of the discriminabililty of stimuli in signal detection tasks canbe influenced by alterations of motivational state. In the present study, rats performed an operant signal detection procedure that required the completion of a fixed number of responses before a stimulus was presented at one of two front cue lamps to separately measure the motivation to respond from the ability to respond accurately. One manipulation, presession water access, affected the speed and frequency that trials were initiated, but did not affect response accuracy. In contrast, a flashing houselight during thesession, and i.p. ((5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d,] cyclohepten-5,10-imine (dizocilpine or MK-801), a glutamate N-methyl-D-aspartate receptor antagonist, impaired response accuracy in a stimulus duration-dependent manner. These results suggest that it is possible to procedurallyisolate the motivation to respond to stimuli from accuracy of detection, and thereby protect attending from side effects of drugs that influence the motivation to respond. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:08:47