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Titolo:
Mast cell distribution and density in the normal uterus - metachromatic staining using lectins
Autore:
Sivridis, E; Giatromanolaki, A; Agnantis, N; Anastasiadis, P;
Indirizzi:
Democritus Univ Thrace, Gen Hosp Alexandroupolis, Dept Pathol, Alexandroupolis 68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 upolis 68100, Greece Democritus Univ Thrace, Gen Hosp Alexandroupolis, Dept Obstet & Gynaecol, Alexandroupolis 68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 upolis 68100, Greece
Titolo Testata:
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
fascicolo: 1, volume: 98, anno: 2001,
pagine: 109 - 113
SICI:
0301-2115(200109)98:1<109:MCDADI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ENDOMETRIUM; HISTOCHEMISTRY; HETEROGENEITY; FIBROBLASTS; EXPRESSION;
Keywords:
normal endometrium; myometrium; mast cells; Con A; lectins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sivridis, E Democritus Univ Thrace, Gen Hosp Alexandroupolis, Dept Pathol,POB 128, Alexandroupolis 68100, Greece Democritus Univ Thrace POB 128 Alexandroupolis Greece 68100 e
Citazione:
E. Sivridis et al., "Mast cell distribution and density in the normal uterus - metachromatic staining using lectins", EUR J OB GY, 98(1), 2001, pp. 109-113

Abstract

This study investigates the number and die distribution of mast cells in the normal human uterus. Reliability of results was ensured by prompt tissuefixation and the use of biotin-labelled lectins in conjunction with the avidin-biotin peroxidase complex (ABC) method. This design revealed that mastcells are, indeed, normal constituents of the human uterus. They occur in large numbers in the myometrium, but are only scanty in the endometrium where they tend to be confined to the stratum basalis. The mean mast cell counts per high power field (MC/HPF), after staining with Canavalia ensiformis agglutinin (Con A), were 17.9 MC/HPF in the inner half of the myometrium, and 8.3 MC/HPF in the outer half of the myometrium; 2.7 MC/HPF in the basalis, and 0.3 MC/HPF in the functionalis (P < 0.05). There are no apparent differences in the number of mast cells between the normal proliferative and secretory phase endometrium, however, endometrial mast cells are considerably reduced and, apparently, depleted of metachromatic. granules during the immediate pre-menstrual phase of the menstrual cycle. It is presumed that this, almost exclusive, presence of mast cells in the basal layer of the endometrial matrix, combined with the discharge of their cytoplasmic granules towards the end of the cycle, may be related with the contracting process preceding menstruation. On the other hand, the relative paucity of mast cellsin the functional layer may contribute to the immune tolerance of the gestational endometrium to the implantation of the blastocyst. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:32:17