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Titolo:
Effect of vagal nerve stimulation on auditory and visual event-related potentials
Autore:
Brazdil, M; Chadim, P; Daniel, P; Kuba, R; Rektor, I; Novak, Z; Chrastina, J;
Indirizzi:
Masaryk Univ, St Annes Hosp, Epilepsy Ctr Brno, Dept Neurol, Brno, Czech Republic Masaryk Univ Brno Czech Republic rno, Dept Neurol, Brno, Czech Republic Masaryk Univ, St Annes Hosp, Epilepsy Ctr Brno, Dept Neurosurg, Brno, Czech Republic Masaryk Univ Brno Czech Republic , Dept Neurosurg, Brno, Czech Republic
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 457 - 461
SICI:
1351-5101(200109)8:5<457:EOVNSO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOKED-POTENTIALS; P300;
Keywords:
cognitive functions; intractable epilepsy; P3; vagal nerve stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Brazdil, M Masaryk Univ, St Annes Hosp, Epilepsy Ctr Brno, Dept Neurol, Brno, Czech Republic Masaryk Univ Brno Czech Republic eurol, Brno, Czech Republic
Citazione:
M. Brazdil et al., "Effect of vagal nerve stimulation on auditory and visual event-related potentials", EUR J NEUR, 8(5), 2001, pp. 457-461

Abstract

Chronic unilateral vagal nerve stimulation (VNS) has been recently introduced into the therapy for intractable epileptic seizures. Its effect on cognitive functions in VNS-treated patients remains controversial. The aim of the present study was to evaluate the possible impact of therapeutic VNS on cognitive functions by means of event-related potentials analysis. Ten patients with medically intractable epilepsy, who had been implanted with VNS devices, participated in the study. Auditory and visual event-related potentials (ERPs) were repeatedly recorded, first just before the implantation ofVNS devices, and then again 3-6 months after the device activation. The effect of lower intensity stimulation on the P3 component of ERPs was assessed. No significant differences were found in auditory ER-Ps; the latencies of P3 as well as N2/P3 peak-to-peak amplitudes were virtually identical. Thesame was true for mean P3 latencies of visual ERPs. However, higher visualN2/P3 peak-to-peak amplitudes were observed in the responses to targets that followed VNS, with a significant finding at the electrodes investigated. When comparing the effect of VNS on visual N2/P3 amplitude in each electrode separately, the most expressive differences were found in the frontal region. This observation supports the theory of a possible positive effect oflow-intensity VNS on the cognitive functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:36:47