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Titolo:
Side-effects of intradermal injections of botulinum A toxin in the treatment of palmar hyperhidrosis: a neurophysiological study
Autore:
Swartling, C; Farnstrand, C; Abt, G; Stalberg, E; Naver, H;
Indirizzi:
Univ Uppsala, Inst Med Sci, S-75105 Uppsala, Sweden Univ Uppsala UppsalaSweden S-75105 nst Med Sci, S-75105 Uppsala, Sweden Univ Uppsala, Inst Neurosci, S-75105 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75105 st Neurosci, S-75105 Uppsala, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 451 - 456
SICI:
1351-5101(200109)8:5<451:SOIIOB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL HYPERHIDROSIS; AXILLARY HYPERHIDROSIS; DOUBLE-BLIND; A TOXIN; THERAPY; TENSION; TRIAL;
Keywords:
afferent C-fibre function; botulinum toxin; EMG; hyperhidrosis; side-effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Swartling, C Univ Uppsala Hosp, Dept Dermatol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 85 Uppsala, Sweden
Citazione:
C. Swartling et al., "Side-effects of intradermal injections of botulinum A toxin in the treatment of palmar hyperhidrosis: a neurophysiological study", EUR J NEUR, 8(5), 2001, pp. 451-456

Abstract

Focal palmar hyperhidrosis can be effectively abolished by intradermal injections with botulinum toxin. Muscle weakness of finger grip has been reported as a reversible side-effect of this new treatment. The objective of this work was to measure muscular side-effects after treatment of palmar hyperhidrosis with botulinum toxin. As botulinum toxin has been used in the treatment of pain, we studied whether the toxin might influence afferent thin-fibre function by measuring temperature perception thresholds. Thirty-seven patients treated with botulinum toxin (Botox, Allergan Pharmaceuticals, Irvine, CA, USA) showed a decrease in compound muscle action potential (CMAP) for both abductor pollicis brevis (APB) and abductor digiti minimi (ADM) compared with pre-injection values on average by 64 and 36%, respectively, at3 weeks which returned nearly to normal at 37 weeks. Muscle power for bothfinger abduction and finger opposition decreased to a lesser extent. Repetitive nerve stimulation and single fibre electromyography (EMG) showed a disturbed neuromuscular transmission. Thus, despite careful technique with small doses of botulinum toxin injected intradermally, the toxin diffuses to underlying muscles. With regard to the present results, one should be careful in using higher doses of Botox than 0.8 mU/cm(2) in the palmar skin above intrinsic muscles. No influence on thin-fibre function was seen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/08/20 alle ore 18:47:45