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Titolo:
Review of the functional surgical treatment of dystonia
Autore:
Krack, P; Vercueil, L;
Indirizzi:
Univ Kiel, Dept Neurol, D-24105 Kiel, Germany Univ Kiel Kiel Germany D-24105 Kiel, Dept Neurol, D-24105 Kiel, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 389 - 399
SICI:
1351-5101(200109)8:5<389:ROTFST>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED PARKINSONS-DISEASE; INTERNAL GLOBUS-PALLIDUS; TERM FOLLOW-UP; UNILATERAL POSTEROVENTRAL PALLIDOTOMY; SUBTHALAMIC NUCLEUS STIMULATION; CHRONIC ELECTRICAL-STIMULATION; ONSET GENERALIZED DYSTONIA; INDUCED TARDIVE-DYSKINESIA; POSTERIOR GPI PALLIDOTOMY; THALAMIC-STIMULATION;
Keywords:
deep brain stimulation; dystonia; pallidotomy; thalamotomy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
135
Recensione:
Indirizzi per estratti:
Indirizzo: Krack, P Univ Kiel, Dept Neurol, Niemannsweg 147, D-24105 Kiel, Germany Univ Kiel Niemannsweg 147 Kiel Germany D-24105 105 Kiel, Germany
Citazione:
P. Krack e L. Vercueil, "Review of the functional surgical treatment of dystonia", EUR J NEUR, 8(5), 2001, pp. 389-399

Abstract

A review of functional surgery for dystonia is presented. Recently renewedinterest in stereotaxy for dystonia has followed the resurgence of pallidotomy and the introduction of deep brain stimulation (DBS) in Parkinson's disease (PD) in the early 1990s. However, even since the 1950s, small series of patients treated with ablative surgery have been carefully studied, providing useful information, notably regarding the tolerability of surgery. Inthe setting of dystonia, thalamotomy was first performed with substantial benefits, but some authors outlined the great variability in outcome, and the high incidence of operative side-effects. In the 'modern' era of functional surgery for movement disorders, the globus pallidus internus (GPi) has emerged to be currently the best target for dystonia, based on small seriesof patients published in the last few years. Both bilateral posteroventralpallidotomy (PVP) and bilateral pallidal stimulation, performed by severalteams, have benefited a variety of patients with severe dystonia, the mostdramatic improvements being seen in primary dystonia with a mutation in the DYT1 gene. Whereas patients with secondary dystonia have often shown a lesser degree of improvement, some publications have nevertheless reported major benefit. There is today a strong need for carefully controlled studies comparing secondary and primary dystonia, DYT1 and non-DYT1 dystonia, ablative surgery and DBS, with additional assessment of neuropsychological changes, especially in children treated with bilateral pallidal procedures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:22:25