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Titolo:
Circulating leptin concentrations and ovarian function in polycystic ovarysyndrome
Autore:
Pirwany, IR; Fleming, R; Sattar, N; Greer, IA; Wallace, AM;
Indirizzi:
Royal Victoria Hosp, McGill Reproduct Ctr, Div Reproduct Endocrinol & Infertil, Dept Obstet & Gynecol, Montreal, PQ H3A 1A1, Canada Royal Victoria Hosp Montreal PQ Canada H3A 1A1 ntreal, PQ H3A 1A1, Canada Univ Glasgow, Royal Infirm, Dept Obstet & Gynecol, Glasgow G31 2ER, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G31 2ER ow G31 2ER, Lanark, Scotland Royal Infirm, Dept Biochem, Glasgow G31 2ER, Lanark, Scotland Royal Infirm Glasgow Lanark Scotland G31 2ER ow G31 2ER, Lanark, Scotland
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 3, volume: 145, anno: 2001,
pagine: 289 - 294
SICI:
0804-4643(200109)145:3<289:CLCAOF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE; INSULIN-RESISTANCE; MENSTRUAL-CYCLE; GROWTH-FACTOR; FEMALE MICE; OBESE GENE; WOMEN; PLASMA; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Pirwany, IR Royal Victoria Hosp, McGill Reproduct Ctr, Div Reproduct Endocrinol & Infertil, Dept Obstet & Gynecol, Womens Pavill,F6-58,687 Pine Ave W, Montreal, PQ H3A 1A1, Canada Royal Victoria Hosp Womens Pavill,F6-58,687 Pine Ave W Montreal PQ Canada H3A 1A1
Citazione:
I.R. Pirwany et al., "Circulating leptin concentrations and ovarian function in polycystic ovarysyndrome", EUR J ENDOC, 145(3), 2001, pp. 289-294

Abstract

Objective: Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction. Although the role of leptin in the control of reproduction is unclear, it may be involved in the control of ovulation. The aim of this cross-sectional study was to determine the relationship between circulating leptin concentrations, and anthropometric, metabolic and endocrine variables as well as to examine a possible role of leptin in ovarian dysfunction associated with PCOS. Design: Prospective observational study. Methods: Seventy-one subjects with PCOS and 23 body mass index (BMI)-matched control subjects were recruited from infertility clinics. The association between serum leptin concentrations and the above variables was measured outwith the luteal phase. A subgroup of 24 PCOS subjects underwent more frequent blood sampling to monitor follicular growth and ovulation. The association between variables was measured by univariate, multivariate and partial correlation analyses. Results: Serum leptin concentrations were not different in subjects with PCOS and controls, and were strongly associated with BMI in both groups. Twelve patients ovulated during the study period. There was no significant difference in serum leptin concentrations between ovulatory and anovulatory subjects. The relationship between BMI and leptin was similar in both groups. Conclusion: The results indicated that circulating leptin concentrations relate principally to total body fat in subjects with PCOS and controls, andthat this is not associated with the facility for follicular development and ovulation in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:03:13