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Titolo:
Surgical results for multiple primary lung cancers
Autore:
Rea, F; Zuin, A; Callegaro, D; Bortolotti, L; Guanella, G; Sartori, F;
Indirizzi:
Univ Padua, Policlin Univ, Div Thorac Surg, I-35128 Padua, Italy Univ Padua Padua Italy I-35128 iv, Div Thorac Surg, I-35128 Padua, Italy
Titolo Testata:
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 489 - 494
SICI:
1010-7940(200109)20:3<489:SRFMPL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BRONCHOGENIC CARCINOMA; RESECTION; 2ND; DIAGNOSIS; SYSTEM;
Keywords:
lung; bronchial cancer; multiple cancer; resection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Rea, F Univ Padua, Policlin Univ, Div Thorac Surg, I-35128 Padua, Italy Univ Padua Padua Italy I-35128 Thorac Surg, I-35128 Padua, Italy
Citazione:
F. Rea et al., "Surgical results for multiple primary lung cancers", EUR J CAR-T, 20(3), 2001, pp. 489-494

Abstract

Objective: The development of a multiple primary lung cancer (MPLC) is notrare in long-term survivors after curative resections. We analysed our experience in order to verify surgical results and long-term survival in our patients. Methods: From 1971 to 1999, 80 patients with MPLC (two tumours each, total 160) were treated at the Division of Thoracic Surgery of the University of Padua. Our criteria for the definition of a synchronous or metachronous cancer are those proposed by Martini and Melamed. We had 19 patients with a synchronous tumour and 61 patients with a metachronous tumour. We performed 95 lobectomies, 5 completion pneumonectomies and 53 segmentectomies. Of 160 MPLCs, 60 were squamous carcinomas, 78 adenocarcinomas, 8 small cell lung cancers, 9 large cell lung cancers and 5 other tumours. Of 160 MPLCs, 140 were N0 disease (87.5%) and 20 were N1 or N2 disease (12.5%). Results: The overall 30-day mortality was 2.5% (2 patients). Eighteen patients (22.5%) had postoperative complications. Survival at 5 and 10 years for all patients was 72% and 58%, respectively. Five-year survival for patients withmetachronous and synchronous disease from the time of initial diagnosis ofcancer was 85% and 20% (P=0.001), and 10-year survival was 58% and 0% (P=0.001), respectively. Survival after the development of a metachronous lesion was 51% at 5 years and 20% at 10 years. The 5-year survival of patients with metachronous tumours undergoing standard surgical procedures of the second tumour was 52%; the 5-year survival of patients undergoing atypical or segmental resections was 55%. Conclusions: Careful follow-up is recommendedin all patients surviving curative resection. More accurate selection criteria for MPLC is required. An aggressive surgical approach is justified in patients with MPLC and offers the greatest chance for long-term survival even in the case of limited resection. (C)2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:42:29