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Titolo:
Pneumonectomy for non-Small cell lung cancer: predictors of operative morality and survival
Autore:
Alexiou, C; Beggs, D; Rogers, ML; Beggs, L; Asopa, S; Salama, FD;
Indirizzi:
City Hosp, Dept Cardiothorac Surg, Nottingham NG5 1PB, England City Hosp Nottingham England NG5 1PB c Surg, Nottingham NG5 1PB, England
Titolo Testata:
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 476 - 480
SICI:
1010-7940(200109)20:3<476:PFNCLC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM SURVIVAL; BRONCHOGENIC-CARCINOMA; RESECTION; MORTALITY; SURGERY; COMPLICATIONS; PROGNOSIS; CAPACITY; AGE;
Keywords:
pneumonectomy; operative mortality; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Beggs, D City Hosp, Dept Cardiothorac Surg, Nottingham NG5 1PB, England City Hosp Nottingham England NG5 1PB ottingham NG5 1PB, England
Citazione:
C. Alexiou et al., "Pneumonectomy for non-Small cell lung cancer: predictors of operative morality and survival", EUR J CAR-T, 20(3), 2001, pp. 476-480

Abstract

Objective: The purpose of this study was to identify predictors of operative mortality and survival following pneumonectomy for nonsmall cell lung cancer (NSCLC). Methods: All 206 patients having a pneumonectomy for NSCLC between 1991 and 1997 in our unit were prospectively studied. There were 162 males (79%) and 44 females (21%) with a mean age (+/- standard deviation) of 61 +/- 7.7 years (range 34-81 years). Squamous cell (75%) and adenocarcinoma (17.0%) were the predominant histological types. The possible impact of29 parameters on operative mortality and survival was tested with univariate and multivariate analysis. The mean follow-up was 2.3 +/- 1.2 years, ranging between 0 and 6.8 years, and it was complete. Results: Operative mortality was 6.8% (14 deaths). On multiple logistic regression older age (P = 0.04) and the development post-operatively of bronchopleural fistula (BPF) (P = 0.01) were independent predictors of operative mortality. The overall, Kaplan-Meier, 1-, 3- and 5-year survival (+/- standard error from the mean), inclusive of operative mortality, was 68 +/- 3.3, 42 +/- 4.1 and 35 +/- 4.5%. On Cox proportional hazards regression adenocarcinoma (P = 0.006), thedevelopment of BPF (P = 0.003), older age (P = 0.03) and higher pathological stage (P = 0.02) were independent adverse predictors of survival. Conclusion: Pneumonectomy for NSCLC carries a considerable, but acceptable, operative mortality and provides an important survival benefit. This study suggests that older age and BPF are major determinants of an unfavourable in-hospital outcome; older age, BPF, adenocarcinoma cell type and higher pathological stage significantly reduce the probability of a long-term survival. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:12:45