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Titolo:
Variability in aflatoxin-albumin adduct levels and effects of hepatitis B and C virus infection and glutathione S-transferase M1 and T1 genotype
Autore:
Ahsan, H; Wang, LY; Chen, CJ; Tsai, WY; Santella, RM;
Indirizzi:
Columbia Univ, Dept Epidemiol, New York, NY USA Columbia Univ New York NYUSA bia Univ, Dept Epidemiol, New York, NY USA Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY USA Columbia Univ New York NY USA ving Comprehens Canc Ctr, New York, NY USA Columbia Univ, Dept Environm Hlth Sci, New York, NY USA Columbia Univ NewYork NY USA , Dept Environm Hlth Sci, New York, NY USA Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol, Taipei, Taiwan Natl Taiwan Univ Taipei Taiwan ubl Hlth, Inst Epidemiol, Taipei, Taiwan Columbia Univ, Dept Biostat, New York, NY USA Columbia Univ New York NY USA umbia Univ, Dept Biostat, New York, NY USA
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
fascicolo: 8, volume: 109, anno: 2001,
pagine: 833 - 837
SICI:
0091-6765(200108)109:8<833:VIAALA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPUBLIC-OF-CHINA; HEPATOCELLULAR-CARCINOMA; INCREASED RISK; CANCER RISK; EXPOSURE; DNA;
Keywords:
aflatoxin-albumin adducts; biomarkers; intraindividual variability; liver cancer; molecular epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Ahsan, H Columbia Presbyterian Med Ctr, Div Epidemiol, Room PH-18-129,622 W 168th St, New York, NY 10032 USA Columbia Presbyterian Med Ctr Room PH-18-129,622 W 168th St New York NY USA 10032
Citazione:
H. Ahsan et al., "Variability in aflatoxin-albumin adduct levels and effects of hepatitis B and C virus infection and glutathione S-transferase M1 and T1 genotype", ENVIR H PER, 109(8), 2001, pp. 833-837

Abstract

Exposure to aflatoxin B-1 (AFB(1)), an important cofactor in the etiology of hepatocellular carcinoma in Taiwan, is influenced by dietary and other factors. The present study examined the intraindividual variability in AFB(1)-albumin adducts, the most reliable long-term biomarker of AFB(1) exposure, and whether the baseline or follow-up adduct levels and the intraindividual variability in adduct levels are modified by endogenous and environmental factors. The study measured AFB(1)-albumin adduct levels among 264 healthy male residents of three townships (Hu-Hsi, Ma-Kung, and Pai-Hsa) of Penghu Islets, Taiwan, at two different time points with a median interval of 1.68 years (range 1.00-3.17 years). There was a generalized reduction in the adduct levels, with the median values being 22.1 pmol/mg (range 5.0-355.8 pmol/mg) at time 1 and 14.3 pmol/mg (range 5.0-205.2 pmol/mg) at time 2. This intraindividual variability in adduct levels was inversely associated with the age of subjects and the tirne interval between the two blood draws. The variability in adduct levels was lower among subjects in Hu-Hsi and Pai-Hsa townships as compared to those in Ma-Kung. No significant association was observed for the intraindividual variability in AFB(1)-albumin adducts with regard to the season when blood was drawn. There was also no significant association between intraindividual variability and hepatitis B surface antigen, anti-hepatitis C virus (anti-HCV, glutathione S-transferase (GST) M1, or GSTT1 status. In conclusion, we found substantial intraindividual variability in the AFB(1) exposure (as determined by AFB(1)-albumin adducts) in Taiwan, which was probably more likely related to dietary or other environmental influences rather than to endogenous factors (e.g., hepatitis B/C viral infection or GST M1/T1 genetic status).

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Documento generato il 25/11/20 alle ore 03:28:51