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Titolo:
Immunohistochemical analysis of p27 (Kip1) in human pituitary glands and in various types of pituitary adenomas
Autore:
Komatsubara, K; Tahara, S; Umeoka, K; Sanno, N; Termaoto, A; Osamura, RY;
Indirizzi:
Nippon Med Coll, Dept Neurosurg, Bunkyo Ku, Tokyo 1138603, Japan Nippon Med Coll Tokyo Japan 1138603 urg, Bunkyo Ku, Tokyo 1138603, Japan Tokai Univ, Sch Med, Dept Pathol, Kanagawa 2591100, Japan Tokai Univ Kanagawa Japan 2591100 , Dept Pathol, Kanagawa 2591100, Japan
Titolo Testata:
ENDOCRINE PATHOLOGY
fascicolo: 2, volume: 12, anno: 2001,
pagine: 181 - 188
SICI:
1046-3976(200122)12:2<181:IAOP(I>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT KINASE INHIBITOR; GROWTH-FACTOR-BETA; CELL-CYCLE ARREST; P27(KIP1) EXPRESSION; CDK INHIBITORS; MICE LACKING; PROGRESSION; TUMORS; PROLIFERATION; HYPERPLASIA;
Keywords:
p27; pituitary adenoma; cell proliferation; cyclin-dependent-kinase (CDK) inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Komatsubara, K Nippon Med Coll, Dept Neurosurg, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan Nippon Med Coll 1-1-5 Sendagi Tokyo Japan 1138603 3, Japan
Citazione:
K. Komatsubara et al., "Immunohistochemical analysis of p27 (Kip1) in human pituitary glands and in various types of pituitary adenomas", ENDOCR PATH, 12(2), 2001, pp. 181-188

Abstract

p27 (Kip1) plays regulatory roles in the cell cycle by inhibiting the activity of cyclin dependent kinases (CDKs). This immunohistochemical study is aimed at elucidating the expression of p27 in human pituitary and in various types of pituitary adenomas in order to clarify its role in the regulation of proliferation. Sixteen normal pituitary glands and 179 human pituitary adenomas were usedfor immunohistochemical studies. The tissues were fixed in 10% formalin and embedded in paraffin. Indirect peroxidase method was performed after heat-induced antigen retrieval using a monoclonal antibody against p27 protein.p27 protein was expressed in the nuclei of all 16 normal human pituitary glands. p27 protein was also expressed in 128 of 179 cases of pituitary adenomas (71.5%). A marked decrease of p27 expression was noted in ACTH-secreting adenomas, 8/20 (40.0%), compared with other types of pituitary adenomas-GH-secreting adenomas, 35/46 (76.1%); PRL-secreting adenomas, 22/33 (66.7%); TSH-secreting adenomas, 8/11 (72.7%); and nonfunctioning adenomas, 55/69 (79.7%). These results suggest that p27 may play some role in the regulation of proliferation in all types of pituitary adenomas. The lower levels of p27 in ACTH-secreting adenoma is of particular interest with respect to the intermediate lobe-derived pituitary tumor developed in p27 knockout mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:44:32