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Titolo:
Regulation of cardiac transient outward potassium current by norepinephrine in normal and diabetic rats
Autore:
Gallego, M; Casis, O;
Indirizzi:
Univ Basque Country, Sch Pharm, Dept Physiol, Bilbao 48080, Spain Univ Basque Country Bilbao Spain 48080 Dept Physiol, Bilbao 48080, Spain
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 4, volume: 17, anno: 2001,
pagine: 304 - 309
SICI:
1520-7552(200107/08)17:4<304:ROCTOP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR MYOCYTES; K+ CURRENT; ADRENOCEPTOR STIMULATION; KV4.3; CELLS; CHANNELS; HEART;
Keywords:
heart; K-channel; norepinephrine; diabetes; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Casis, O Univ Basque Country, Sch Pharm, Dept Physiol, POB 699, Bilbao 48080, Spain Univ Basque Country POB 699 Bilbao Spain 48080 lbao 48080, Spain
Citazione:
M. Gallego e O. Casis, "Regulation of cardiac transient outward potassium current by norepinephrine in normal and diabetic rats", DIABET M R, 17(4), 2001, pp. 304-309

Abstract

Background alpha -Adrenergic stimulation regulates cardiac contractility by reducing repolarising K+ currents. Despite this, no published work existson the effects of norepinephrine on isolated cardiac transient outward current, responsible for action potential duration in the rat and human. Besides, diabetes alters cardiac inotropic responses to sympathetic innervation,and this can result from altered responsiveness of the transient outward current to norepinephrine. Methods Transient outward K+ current was measured using the whole-cell configuration of the patch-clamp technique. Myocytes were isolated from the right ventricle of healthy and streptozotocin-induced diabetic rats. Results Norepinephrine, through alpha (1)-adrenoceptors, reduces current amplitude in a concentration-dependent way, with no effects on current kinetics or voltage dependence of inactivation. Diabetes reduces current amplitude and accelerates its inactivation process. Norepinephrine also reduces cur-rent amplitude in diabetic cells; however diabetes shifts to the right the concentration-response curve and reduces the maximum effect of the neurotransmitter. Conclusions Norepinephrine reduces the amplitude of isolated ventricular transient outward K+ current with no effects on current properties in myocytes isolated from either healthy or diabetic hearts. Diabetes shifts the concentration-response curve; thus diabetic myocytes are more resistant to sympathetic regulation than are healthy cells. Copyright (C) 2001 John Wiley &Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:29:18