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Titolo:
No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility
Autore:
Pociot, F; Larsen, ZM; Zavattari, P; Deidda, E; Nerup, J; Cattaneo, M; Chiaramonte, R; Comi, P; Sabbadini, M; Zollo, M; Biunno, I; Cucca, F;
Indirizzi:
Steno Diabet Ctr, DK-2820 Gentofte, Denmark Steno Diabet Ctr Gentofte Denmark DK-2820 Ctr, DK-2820 Gentofte, Denmark Univ Cagliari, Dipartimento Sci Biomed & Biotecnol, I-09121 Cagliari, Italy Univ Cagliari Cagliari Italy I-09121 Biotecnol, I-09121 Cagliari, Italy Univ Milan, Dipartimento Sci Biomed & Biotecnol, I-20090 Segrate, Italy Univ Milan Segrate Italy I-20090 med & Biotecnol, I-20090 Segrate, Italy TIGEM, I-20132 Milan, Italy TIGEM Milan Italy I-20132TIGEM, I-20132 Milan, Italy TIGEM, I-80131 Naples, Italy TIGEM Naples Italy I-80131TIGEM, I-80131 Naples, Italy
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 4, volume: 17, anno: 2001,
pagine: 292 - 295
SICI:
1520-7552(200107/08)17:4<292:NEFSAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; CAENORHABDITIS-ELEGANS SEL-1; DIFFERENTIATION; LINKAGE; CELL; ASSOCIATION; APOPTOSIS; HOMOLOG; IDDM;
Keywords:
type 1 diabetes; IDDM11; candidate gene; genetics; pancreas development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Pociot, F Steno Diabet Ctr, Niels Steensensvej 2, DK-2820 Gentofte, Denmark Steno Diabet Ctr Niels Steensensvej 2 Gentofte Denmark DK-2820
Citazione:
F. Pociot et al., "No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility", DIABET M R, 17(4), 2001, pp. 292-295

Abstract

Background The SEL1L gene is located on human chromosome 14q24.3-31 close to D14S67 which has been previously proposed to be a type 1 diabetes mellitus locus (IDDM11). Sel-1 is a negative regulator of the Notch signalling pathway and SEL1L is selectively expressed in adult pancreas and islets of Langerhans. This suggests that SEL1L may be a candidate gene for IDDM11. Methods We have analysed two newly identified CA-repeat polymorphisms within the genomic sequence of the SEL1L locus for association with type 1 diabetes mellitus (T1DM) in 152 Danish T1DM-affected sib-pair families and in 240 Sardinian families (229 simplex and 11 sib-pair families). Results No evidence for association of the two SEL1L markers with T1DM wasobserved in either the Danish or the Sardinian families. We have also usedallelic sharing methods to analyse linkage with T1DM in the IDDM11 region using the same markers and the Danish collection of affected sib-pair families. No evidence of linkage was observed (Z(max) = 0.86). Conclusion Although several lines of evidence suggest that SEL1L might be a candidate for IDDM11-conferred susceptibility to T1DM the present study does not support this hypothesis. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/12/19 alle ore 03:49:52