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Titolo:
Prostaglandylinositol cyclic phosphate (cPIP): a novel second messenger ofinsulin action. Comparative analysis of two kinds of 'insulin mediators'
Autore:
Shashkin, PN; Wasner, HK; Ortmeyer, HK; Hansen, BC;
Indirizzi:
Univ Maryland, Sch Med, Dept Physiol, Obes & Diabet Res Ctr, Baltimore, MD21201 USA Univ Maryland Baltimore MD USA 21201 abet Res Ctr, Baltimore, MD21201 USA Univ Dusseldorf, Diabet Forschungsinst, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 4, volume: 17, anno: 2001,
pagine: 273 - 284
SICI:
1520-7552(200107/08)17:4<273:PCP(AN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; FATTY-ACID COMPOSITION; PHOSPHOLIPASE C-GAMMA; RAT SKELETAL-MUSCLE; LIVER PLASMA-MEMBRANES; IRS-SIGNALING SYSTEM; GREEN TEA CATECHIN; RECEPTOR SUBSTRATE-1; AMP ANTAGONIST; PHOSPHATIDYLINOSITOL 3-KINASE;
Keywords:
prostaglandylinositol cyclic phosphate; inositolphosphoglycan; phospholipase A(2); cyclo-oxygenase; phospholipase C; IRS-1; insulin action; rhesus monkey; Macaca mulatta;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
128
Recensione:
Indirizzi per estratti:
Indirizzo: Shashkin, PN Univ Virginia, Room 5147 MR4,Lane Rd POB 801 405, Charlottesville, VA 22908 USA Univ Virginia Room 5147 MR4,Lane Rd POB 801 405 Charlottesville VA USA 22908
Citazione:
P.N. Shashkin et al., "Prostaglandylinositol cyclic phosphate (cPIP): a novel second messenger ofinsulin action. Comparative analysis of two kinds of 'insulin mediators'", DIABET M R, 17(4), 2001, pp. 273-284

Abstract

Insulin induces a broad spectrum of effects over a wide time interval. It also stimulates the phosphorylation of some cellular proteins, while decreasing the state of phosphorylation of others. These observations indicate the presence of different, but not necessarily mutually exclusive, pathways of insulin action. One well-known pathway represents a phosphorylation cascade initiated by the tyrosine kinase activity of the insulin receptor followed by involvement of different MAP-kinases. Another pathway suggests the existence of low molecular weight insulin mediators whose synthesis and/or release is initiated by insulin. Comparable analysis of two kinds of insulin mediators, namely inositolphosphoglycans and prostaglandylinositol cyclic phosphate (cPIP), has been carried out. It has been shown that the expression of a number of enzymes, such as phospholipase A(2), phospholipase C, cyclooxygenase and IRS-1-like enzyme, could regulate the biosynthesis of cPIP in both normal and diabetes-related conditions. Data on the activity of a key enzyme of cPIP biosynthesis termed cPIP synthase (IRS-1-like enzyme) in various monkey tissues before and twice during an euglycemic hyperinsulinemic clamp have been presented. it has been concluded that in vivo insulin increases cPIP synthase activity in both liver and subcutaneous adipose tissueof lean normal monkeys. It has been also suggested that abnormal production of cPIP could be related to several pathologies including glucocorticoid-induced insulin resistance and diabetic embryopathy. Further studies on cPIP and other types of insulin mediators are necessary to aid our understanding of insulin action. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 10:17:55