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Titolo:
Cardiac sympathetic innervation and blood flow regulation of the diabetic heart
Autore:
Schnell, O;
Indirizzi:
Diabet Res Inst, D-80804 Munich, Germany Diabet Res Inst Munich Germany D-80804 Res Inst, D-80804 Munich, Germany
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 4, volume: 17, anno: 2001,
pagine: 243 - 245
SICI:
1520-7552(200107/08)17:4<243:CSIABF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 METAIODOBENZYLGUANIDINE; AUTONOMIC NEUROPATHY; IDDM PATIENTS; MELLITUS; DYSINNERVATION; DYSFUNCTION;
Keywords:
diabetes mellitus; diabetic neuropathy; sympathetic dysfunction; heart failure; nitric oxide;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Schnell, O Diabet Res Inst, Kolner Pl 1, D-80804 Munich, Germany Diabet Res Inst Kolner Pl 1 Munich Germany D-80804 ch, Germany
Citazione:
O. Schnell, "Cardiac sympathetic innervation and blood flow regulation of the diabetic heart", DIABET M R, 17(4), 2001, pp. 243-245

Abstract

A key problem in ischemia-induced impairment of the vascular performance of the diabetic heart is the often-unrecognized cardiac sympathetic dysfunction. Advanced single-photon emission computed tomography (SPECT) and positron emission tomography (PET) using the radiopharmaceuticals, I-123-metaiodobenzylguanidine (I-123-MIBG) and C-11-hydroxyephedrine (C-11-HED), have shown that dysfunction of cardiac sympathetic nerves is present to a large extent in both type I and type 2 diabetes. The pattern of sympathetic disturbances is heterogeneous with a predominant effect in the posterior myocardialregion. Furthermore, myocardial blood flow assessment with PET has shown that endothelial-dependent vasodilatation is reduced in proportion to the magnitude of cardiac sympathetic dysfunction. These mechanisms are currently proposed to lead from early changes to advanced impairment of cardiac function in diabetes. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 02:01:53