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Titolo:
Wnt signaling and PKA control Nodal expression and left-right determination in the chick embryo
Autore:
Rodriguez-Esteban, C; Capdevila, J; Kawakami, Y; Belmonte, JCI;
Indirizzi:
Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA Salk InstBiol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 16, volume: 128, anno: 2001,
pagine: 3189 - 3195
SICI:
0950-1991(200108)128:16<3189:WSAPCN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-RIGHT ASYMMETRY; BETA-CATENIN; AXIS FORMATION; XENOPUS; EMBRYOGENESIS; GENE; MECHANISMS; INDUCTION; PATTERNS;
Keywords:
beta-catenin; left-right; Nodal; PKA; sonic hedgehog; TGF beta; Wnt; chick;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Belmonte, JCI Salk Inst Biol Studies, Gene Express Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA Salk Inst Biol Studies 10010 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
C. Rodriguez-Esteban et al., "Wnt signaling and PKA control Nodal expression and left-right determination in the chick embryo", DEVELOPMENT, 128(16), 2001, pp. 3189-3195

Abstract

Expression of the Nodal gene, which encodes a member of the TGF beta superfamily of secreted factors, localizes to the left side of the developing embryo in all vertebrates examined so far. This asymmetric pattern correlateswith normal development of the left-right axis. We now show that the Wnt and PKA signaling pathways control left-right determination in the chick embryo through Nodal. A Wnt/beta -catenin pathway controls Nodal expression inand around Hensen's node, without affecting the upstream regulators Sonic hedgehog, Car and Fibroblast Growth Factor 8. Transcription of Nodal is also positively regulated by a protein kinase A-dependent pathway. Both the adhesion protein N-cadherin and PKI (an endogenous protein kinase A inhibitor) are localized to the right side of the node and may contribute to restrict Nodal activation by Wnt signaling and PKA to the left side of the node.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:54:01