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Titolo:
Conotruncal myocardium arises from a secondary heart field
Autore:
Waldo, KL; Kumiski, DH; Wallis, KT; Stadt, HA; Hutson, MR; Platt, DH; Kirby, ML;
Indirizzi:
Duke Univ, Med Ctr, Dept Pediat, Div Neonatol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pediat, Div Neonatol, Durham, NC 27710 USA Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Biol & Anat, Augusta, GA 30912 USA Med Coll Georgia, Dept Pharmacol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 pt Pharmacol, Augusta, GA 30912 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 16, volume: 128, anno: 2001,
pagine: 3179 - 3188
SICI:
0950-1991(200108)128:16<3179:CMAFAS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEINS; CARDIAC OUTFLOW TRACT; NEURAL CREST; CHICK-EMBRYO; TRANSCRIPTION FACTOR; CARDIOMYOCYTE DIFFERENTIATION; PRECARDIAC MESODERM; XENOPUS-LAEVIS; INDUCTION; EXPRESSION;
Keywords:
chick-quail chimeras; myocardium; FGF-8; BMP-2; heart development; secondary heart field; outflow tract; conotruncus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Kirby, ML Duke Univ, Med Ctr, Dept Pediat, Div Neonatol, POB 3179, Durham,NC 27710 USA Duke Univ POB 3179 Durham NC USA 27710 179, Durham, NC 27710 USA
Citazione:
K.L. Waldo et al., "Conotruncal myocardium arises from a secondary heart field", DEVELOPMENT, 128(16), 2001, pp. 3179-3188

Abstract

The primary heart tube is an endocardial tube, ensheathed by myocardial cells, that develops from bilateral primary heart fields located in the lateral plate mesoderm. Earlier mapping studies of the heart fields performed inwhole embryo cultures indicate that all of the myocardium of the developedheart originates from the primary heart fields. In contrast, marking experiments in ovo suggest that the atrioventricular canal, atria and conotruncus are added secondarily to the straight heart tube during looping. The results we present resolve this issue by showing that the heart tube elongates during looping, concomitant with accretion of new myocardium. The atria areadded progressively from the caudal primary heart fields bilaterally, while the myocardium. of the conotruncus is elongated from a midline secondary heart field of splanchnic mesoderm beneath the floor of the foregut. Cells in the secondary heart field express Nkx2.5 and Gata-4, as do the cells of the primary heart fields. Induction of myocardium appears to be unnecessaryat the inflow pole, while it occurs at the outflow pole of the heart. Accretion of myocardium at the junction of the inflow myocardium with dorsal mesocardium is completed at stage 12 and later (stage 18) from the secondary heart field just caudal to the outflow tract. Induction of myocardium. appears to move in a caudal direction as the outflow tract translocates caudally relative to the pharyngeal arches. As the cells in the secondary heart field begin to move into the outflow or inflow myocardium, they express HNK-1initially and then MF-20, a marker for myosin heavy chain. FGF-8 and BMP-2are present in the ventral pharynx and secondary heart field/outflow myocardium, respectively, and appear to effect induction of the cells in a manner that mimics induction of the primary myocardium from the primary heart fields. Neither FGF-8 nor BMP-2 is present as inflow myocardium is added fromthe primary heart fields. The addition of a secondary myocardium. to the primary heart tube provides a new framework for understanding several null mutations in mice that cause defective heart development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:31:24