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Titolo:
Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption
Autore:
Feiner, L; Webber, AL; Brown, CB; Lu, MM; Jia, L; Feinstein, P; Mombaerts, P; Epstein, JA; Raper, JA;
Indirizzi:
Univ Penn, Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Neurosci, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Div Cardiovasc, Dept Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dept Med, Philadelphia, PA 19104 USA Rockefeller Univ, New York, NY 10021 USA Rockefeller Univ New York NY USA10021 eller Univ, New York, NY 10021 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 16, volume: 128, anno: 2001,
pagine: 3061 - 3070
SICI:
0950-1991(200108)128:16<3061:TDOS3L>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL CREST CELLS; CONGENITAL HEART-DISEASE; CARDIOVASCULAR DEVELOPMENT; DIGEORGE-SYNDROME; MICE DEFICIENT; RECEPTOR; GROWTH; NEUROPILIN-1; DEFECTS; MOUSE;
Keywords:
semaphorin 3C; mouse; cardiac neural crest; interrupted aortic arch; persistent truncus arteriosus; PlexinA2; chemoattractant; Sema3C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Raper, JA Univ Penn, Sch Med, Dept Neurosci, 1115 RBB 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA Univ Penn 1115 RBB 2-3,421 Curie Blvd Philadelphia PA USA 19104
Citazione:
L. Feiner et al., "Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption", DEVELOPMENT, 128(16), 2001, pp. 3061-3070

Abstract

Semaphorin 3C is a secreted member of the semaphorin gene family. To investigate its function in vivo, we have disrupted the semaphorin 3C locus in mice by targeted mutagenesis. semaphorin 3C mutant mice die within hours after birth from congenital cardiovascular defects consisting of interruption of the aortic arch and improper septation of the cardiac outflow tract. This phenotype is similar to that reported following ablation of the cardiac neural crest in chick embryos and resembles congenital heart defects seen inhumans. Semaphorin 3C is expressed in the cardiac outflow tract as neural crest cells migrate into it. Their entry is disrupted in semaphorin 3C mutant mice. These data suggest that semaphorin 3C promotes crest cell migration into the proximal cardiac outflow tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:43:38