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Titolo:
Clinical use of selective estrogen receptor modulators
Autore:
Fontana, A; Delmas, PD;
Indirizzi:
Hop Edouard Herriot, F-69437 Lyon 03, France Hop Edouard Herriot Lyon France 03 uard Herriot, F-69437 Lyon 03, France
Titolo Testata:
CURRENT OPINION IN RHEUMATOLOGY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 333 - 339
SICI:
1040-8711(200107)13:4<333:CUOSER>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; HEALTHY POSTMENOPAUSAL WOMEN; RALOXIFENE LY139481 HCL; BREAST-CANCER PATIENTS; X-RAY ABSORPTIOMETRY; OVARIECTOMIZED RATS; SERUM-CHOLESTEROL; RANDOMIZED TRIAL; ELDERLY WOMEN; TAMOXIFEN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Delmas, PD Hop Edouard Herriot, Pavillon F, F-69437 Lyon 03, France Hop Edouard Herriot Pavillon F Lyon France 03 Lyon 03, France
Citazione:
A. Fontana e P.D. Delmas, "Clinical use of selective estrogen receptor modulators", CURR OP RH, 13(4), 2001, pp. 333-339

Abstract

The concept of selective estrogen receptor modulators (SERMs) is derived from the observation that tamoxifen, an effective adjuvant therapy of breastcancer that has an antiestrogenic effect on breast tissue, has estrogen-like effects on the skeleton and on plasma lipoproteins. Raloxifene is a SERMthat has undergone extensive clinical investigation in the prevention and treatment of postmenopausal osteoporosis. It prevents bone loss at all skeletal sites, and in a large trial in osteoporotic women, the incidence of vertebral fractures was significantly decreased (relative risk 0.64) after upto 4 years of treatment with raloxifene 60 mg. The decrease of nonvertebral fractures did not reach the level of significance. Raloxifene decreased significantly the incidence of breast cancer (relative risk 0.28) and has noeffect on the risk of endometrial cancer. SERMs are likely to play an important role in the management of postmenopausal women. (C) 2001 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:00:41