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Titolo:
Cytokine gene polymorphisms relevant for the spondyloarthropathies
Autore:
Rudwaleit, M; Hohler, T;
Indirizzi:
Univ Mainz, Med Klin & Poliklin, Mainz, Germany Univ Mainz Mainz Germany niv Mainz, Med Klin & Poliklin, Mainz, Germany Free Univ Berlin, Klinikum Benjamin Franklin, Med Klin 1, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 Klin 1, D-12200 Berlin, Germany
Titolo Testata:
CURRENT OPINION IN RHEUMATOLOGY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 250 - 254
SICI:
1040-8711(200107)13:4<250:CGPRFT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; ANKYLOSING-SPONDYLITIS; TNF-ALPHA; REACTIVE ARTHRITIS; RHEUMATOID-ARTHRITIS; PROMOTER POLYMORPHISM; DINUCLEOTIDE REPEAT; 5'-FLANKING REGION; MONONUCLEAR-CELLS; IL-10 PROMOTER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Hohler, T Univ Klin Mainz, Med Klin & Poliklin, Langenbeckstr 1, D-55101 Mainz, Germany Univ Klin Mainz Langenbeckstr 1 Mainz Germany D-55101 , Germany
Citazione:
M. Rudwaleit e T. Hohler, "Cytokine gene polymorphisms relevant for the spondyloarthropathies", CURR OP RH, 13(4), 2001, pp. 250-254

Abstract

Results of sibling and twin studies suggest that a substantial proportion of susceptibility to spondyloarthropathies arises from genes outside the human leukocyte antigen (HLA) region. There is increasing evidence that the pattern of cytokine secretion influences the course of spondyloarthropathies. A Th2 cytokine pattern (low tumor necrosis factor [TNF]-TNF-alpha low interferon [IFN]-gamma, and high interleukin [IL]-10) dominates in the joints of reactive arthritis patients. For IL-10 and TNF-alpha a substantial proportion of cytokine production is under genetic control and influenced by genetic polymorphisms. Here we review the evidences for association of TNF-a and IL-10 polymorphisms with spondyloarthropathies and their functional implications. (C) 2001 Lippincott Williams & Wilkins. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:41:10