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Titolo:
Notch and Presenilin: a proteolytic mechanism emerges
Autore:
Fortini, ME;
Indirizzi:
Univ Penn, Sch Med, Dept Genet, Stellar Chance Labs, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 ance Labs, Philadelphia, PA 19104 USA
Titolo Testata:
CURRENT OPINION IN CELL BIOLOGY
fascicolo: 5, volume: 13, anno: 2001,
pagine: 627 - 634
SICI:
0955-0674(200110)13:5<627:NAPAPM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; GAMMA-SECRETASE INHIBITORS; CAENORHABDITIS-ELEGANS; ALZHEIMERS-DISEASE; DROSOPHILA-NEUROGENESIS; NUCLEAR TRANSLOCATION; INTRACELLULAR DOMAIN; SIGNAL-TRANSDUCTION; SEL-12 PRESENILIN; BETA-APP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Fortini, ME Univ Penn, Sch Med, Dept Genet, Stellar Chance Labs, Room 709C,422 Curie Blvd, Philadelphia, PA 19104 USA Univ Penn Room 709C,422 Curie Blvd Philadelphia PA USA 19104 A
Citazione:
M.E. Fortini, "Notch and Presenilin: a proteolytic mechanism emerges", CURR OP CEL, 13(5), 2001, pp. 627-634

Abstract

Presenilins are needed for proteolytic processing of transmembrane proteins of the Notch/Lin-12 family and for cleavage of the amyloid precursor protein. Accumulating evidence now strongly implicates Presenilin as the catalytic core of a multiprotein complex that executes an unusual intramembranouscleavage of its substrates. In the case of amyloid precursor protein, thiscleavage contributes to the generation of small, toxic amyloid peptides that trigger the pathological development of Alzheimer's disease. In the Notch/Lin-12 pathway, Presenilin-mediated cleavage of the receptor is a crucialfeature of ligand-induced receptor activation and signal transduction. In this pathway, the Presenilins perform a regulated cleavage event that follows additional processing steps during receptor maturation and ligand-induced ectodomain removal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:56:33