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Titolo:
Integrin tyrosine phosphorylation in platelet signaling
Autore:
Phillips, DR; Prasad, KSS; Manganello, J; Bao, M; Nannizzi-Alaimo, L;
Indirizzi:
COR Therapeut Inc, S San Francisco, CA 94080 USA COR Therapeut Inc S San Francisco CA USA 94080 an Francisco, CA 94080 USA
Titolo Testata:
CURRENT OPINION IN CELL BIOLOGY
fascicolo: 5, volume: 13, anno: 2001,
pagine: 546 - 554
SICI:
0955-0674(200110)13:5<546:ITPIPS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOPROTEIN-IIB-IIIA; ACTIVATED HUMAN PLATELETS; CYTOPLASMIC DOMAIN; BETA(3) INTEGRIN; CELL-ADHESION; GLANZMANN THROMBASTHENIA; POINT MUTATION; SH2 DOMAINS; PTB DOMAIN; PROTEIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, DR COR Therapeut Inc, 256 E Grand Ave, S San Francisco, CA 94080USA COR Therapeut Inc 256 E Grand Ave S San Francisco CA USA 94080
Citazione:
D.R. Phillips et al., "Integrin tyrosine phosphorylation in platelet signaling", CURR OP CEL, 13(5), 2001, pp. 546-554

Abstract

The beta3 integrin cytoplasmic tyrosine (ICY) motif of alpha IIb beta3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the beta -integrin cytoplasmic domain. Platelets from mice lacking beta3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of beta3-integrin signals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:49:18