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Titolo:
Preeclampsia, a pregnancy-specific disease, is associated with fetal monocyte activation
Autore:
Steinborn, A; Sohn, C; Sayehli, C; Niederhut, A; Schmitt, E; Kaufmann, M;
Indirizzi:
Univ Frankfurt, Dept Obstet & Gynecol, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 col, D-60590 Frankfurt, Germany Univ Mainz, Inst Immunol, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 z, Inst Immunol, D-55101 Mainz, Germany
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 100, anno: 2001,
pagine: 305 - 313
SICI:
1521-6616(200109)100:3<305:PAPDIA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANES; PRETERM LABOR; ENDOTHELIAL-CELLS; CORD-BLOOD; INTRAUTERINE INFECTION; CYTOKINE PRODUCTION; FC-RECEPTORS; IN-VITRO; TH2; RELEASE;
Keywords:
fetal immune system; monocyte activation; preeclampsia; inflammatory cytokines; reproductive immunology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Steinborn, A Univ Frankfurt, Dept Obstet & Gynecol, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 Frankfurt, Germany
Citazione:
A. Steinborn et al., "Preeclampsia, a pregnancy-specific disease, is associated with fetal monocyte activation", CLIN IMMUNO, 100(3), 2001, pp. 305-313

Abstract

The maternal syndrome of preeclampsia is an exclusively pregnancy-related illness involving multiple organs and severe forms may be complicated by HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome. Recently, it has been proposed that both normal pregnancy and preeclampsia are associated with a systemic activation of the nonspecific maternal immune system and that, in particular, monocytes have a central role in the adjustment of maternal immune functions in pregnancy. Here we have investigated the role of the fetal nonadaptive immune system in normal term delivery, uncontrollable preterm labor, and preeclampsia. We demonstrate that spontaneous delivery at term as well as preterm occurrence of preeclampsia or HELLP syndrome are accompanied by an increased intracellular production of IL-6 in fetal monocytes, indicating strong activation of this cell type. In contrast, we show that elective cesarean delivery at term in the absence of labor or preterm delivery due to uncontrollable labor are not accompanied by an increased production of IL-6 in these cells. These results suggest that increased IL-6 synthesis in fetal monocytes may be a process occurring in association with normal spontaneous term delivery and that this process obviously occurs in early pregnancy in case of preeclampsia. Therefore, we propose that the activation of fetal monocytes as effectors of the innate immunity may be involved in mechanisms inducing spontaneous term delivery and that the occurrence of preeclampsia may be based on dysfunctions of probably both the maternal and the fetal innate immune system. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:44:02