Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Costimulation of memory T-cells by ICOS: A potential therapeutic target for autoimmunity?
Autore:
Sporici, RA; Perrin, PJ;
Indirizzi:
Univ Penn, Sch Med, Dept Med, Pulm Allergy & Crit Care Sect, Philadelphia,PA 19104 USA Univ Penn Philadelphia PA USA 19104 Care Sect, Philadelphia,PA 19104 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 100, anno: 2001,
pagine: 263 - 269
SICI:
1521-6616(200109)100:3<263:COMTBI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS PATIENTS; MHC GENE-EXPRESSION; IFN-GAMMA; INTERFERON-GAMMA; PROTEOLIPID PROTEIN; CYTOKINE PRODUCTION; CD28 COSTIMULATION; CD28-MEDIATED COSTIMULATION;
Keywords:
autoimmunity; EAE/MS; costimulatory molecules; B7; B7RP-1; CD28; ICOS; T lymphocytes; memory/effector T lymphocytes; immunotherapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Perrin, PJ Univ Penn, Sch Med, Dept Med, Pulm Allergy & Crit Care Sect, 909 BRB II,421 Curie Blvd, Philadelphia, PA 19104 USA Univ Penn 909 BRB II,421 Curie Blvd Philadelphia PA USA 19104 A
Citazione:
R.A. Sporici e P.J. Perrin, "Costimulation of memory T-cells by ICOS: A potential therapeutic target for autoimmunity?", CLIN IMMUNO, 100(3), 2001, pp. 263-269

Abstract

Approaches that target costimulatory receptors are independent of T-cell receptor specificity and may be useful for T-cell-mediated diseases in whichthe antigens involved are not well defined. However, the proper costimulatory pathways need to be targeted. For example, therapies for human T-cell-mediated diseases need to be effective against previously activated memory cells. In this review, we use autoimmune demyelination as a paradigm for established immune-mediated pathogenesis. Studies with the human disease multiple sclerosis and the rodent model experimental autoimmune encephalomyelitis have suggested that the effectiveness of CD28 blockade, as a therapeutic strategy for established autoimmune demyelination, may be limited. ICOS, a receptor that appears to be involved in the costimulation of previously activated T-cells, may be an attractive alternative. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:52:08