Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparability of serum and plasma concentrations of haemostasis activationmarkers
Autore:
Korte, W; Riesen, WF;
Indirizzi:
Kantonsspital, IKCH, Inst Clin Chem & Hematol, CH-9007 St Gallen, Switzerland Kantonsspital St Gallen Switzerland CH-9007 -9007 St Gallen, Switzerland
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 7, volume: 39, anno: 2001,
pagine: 627 - 630
SICI:
1434-6621(200107)39:7<627:COSAPC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; FIBRIN MONOMER; COAGULATION; THROMBIN; SAMPLES; HEPARIN; DISEASE; BLOOD;
Keywords:
prothrombin fragment F1+2; fibrin monomer; D-dimer; prothrombinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Korte, W Kantonsspital, IKCH, Inst Clin Chem & Hematol, CH-9007 St Gallen,Switzerland Kantonsspital St Gallen Switzerland CH-9007 Gallen, Switzerland
Citazione:
W. Korte e W.F. Riesen, "Comparability of serum and plasma concentrations of haemostasis activationmarkers", CLIN CH L M, 39(7), 2001, pp. 627-630

Abstract

Since serum and plasma D-dimer concentrations correlate very well, we evaluated the comparability of other haemostasis activation markers in plasma and serum. Prothrombin fragment F1+2, fibrin monomer and D-dimer concentrations were measured with commercially available immunoassays in serum and plasma. Serum to plasma ratios were evaluated to determine the direct (prothrombin fragment F1+2) and indirect (fibrin monomer, D-dimer) downstream influence of prothrombinase on the serum to plasma comparability. Prothrombin fragment F1+2 serum and plasma concentrations did not correlate (R-2 = 0.09, ns), while an unexpected high degree of correlation was found for fibrin monomer (R-2 = 0.66, p < 0.001), and, as expected, a very good correlation was found for D-dimer (R-2 = 0.94, p < 0.001). Median serum to plasma ratios decreased from prothrombin fragment F1+2 (16.26) to fibrin monomer (2.24, p< 0.001) and D-dimer (1.00, p < 0.001), following a highly linear relationship (R-2 = 0.93). Plasma and serum concentrations of the evaluated markerscorrelate the better the farther from prothrombinase activity the respective marker is generated. Serum is not suitable for prothrombin fragment F1+2measurements, whereas fibrin monomer serum concentrations seem of value for research applications. With the used assay, serum seems an appropriate matrix for clinical D-dimer measurements. This would considerably simplify testing strategies. Validation in further clinical trials is needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:01:02